MEPE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEPE_HUMAN
• UniProt AC: Q9NQ76
• Protein Name: Matrix extracellular phosphoglycoprotein
• Gene Name: MEPE
• Organism: Homo sapiens (Human).
• Sequence Length: 525
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Promotes renal phosphate excretion and modulates mineralization..
• Protein Sequence: MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MRVFCVGLL ------CCCCHHHHH	30.16	24719451
4	Phosphorylation	----MRVFCVGLLLF ----CCCCHHHHHHH	1.65	24719451
8	Phosphorylation	MRVFCVGLLLFSVTW CCCCHHHHHHHHHHH	1.55	24719451
59	Phosphorylation	KRINQELSSKENIVQ HHHHHHHHHHHHHHH	38.31	24505115
60	Phosphorylation	RINQELSSKENIVQE HHHHHHHHHHHHHHH	57.52	24505115
73	Phosphorylation	QERKKDLSLSEASEN HHHHHHCCHHHHHCC	39.73	23532336
100	Phosphorylation	RQRLNKEYSISNKEN HHHHCCHHCCCCCCC	16.95	29978859
101	Phosphorylation	QRLNKEYSISNKENT HHHCCHHCCCCCCCC	22.19	29978859
103	Phosphorylation	LNKEYSISNKENTHN HCCHHCCCCCCCCCC	35.59	29978859
108	Phosphorylation	SISNKENTHNGLRMS CCCCCCCCCCCEEEE	20.15	29978859
115	Phosphorylation	THNGLRMSIYPKSTG CCCCEEEEEECCCCC	16.73	24719451
117	Phosphorylation	NGLRMSIYPKSTGNK CCEEEEEECCCCCCC	9.41	24719451
121	Phosphorylation	MSIYPKSTGNKGFED EEEECCCCCCCCCCC	51.40	24719451
172	Phosphorylation	GEENKENTPRNVLNI CCCCCCCCCCHHHHH	25.39	-
477	N-linked_Glycosylation	HYVPHRQNNSTRNKG ECCCCCCCCCCCCCC	44.36	UniProtKB CARBOHYD
478	N-linked_Glycosylation	YVPHRQNNSTRNKGM CCCCCCCCCCCCCCC	36.10	UniProtKB CARBOHYD
498	Phosphorylation	SWGRQPHSNRRFSSR CCCCCCCCCCCCCCC	38.42	-
504	Phosphorylation	HSNRRFSSRRRDDSS CCCCCCCCCCCCCCC	27.39	-
514	Phosphorylation	RDDSSESSDSGSSSE CCCCCCCCCCCCCCC	31.57	-
516	Phosphorylation	DSSESSDSGSSSESD CCCCCCCCCCCCCCC	42.39	-
518	Phosphorylation	SESSDSGSSSESDGD CCCCCCCCCCCCCCC	34.34	24114839
519	Phosphorylation	ESSDSGSSSESDGD- CCCCCCCCCCCCCC-	41.47	24114839
520	Phosphorylation	SSDSGSSSESDGD-- CCCCCCCCCCCCC--	42.70	24114839
522	Phosphorylation	DSGSSSESDGD---- CCCCCCCCCCC----	49.17	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEPE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEPE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEPE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHK1_HUMAN	CHEK1	physical	19808933
FINC_HUMAN	FN1	physical	28514442
TOM34_HUMAN	TOMM34	physical	28514442
LRP2_HUMAN	LRP2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.