dbPTM

MDAR_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MDAR_ARATH
UniProt AC	P92947
Protein Name	Monodehydroascorbate reductase, chloroplastic/mitochondrial {ECO:0000303\|PubMed:16146528}
Gene Name	MDAR5 {ECO:0000303\|PubMed:16146528}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	493
Subcellular Localization	Isoform MDAR6: Plastid, chloroplast . Isoform MDAR5: Mitochondrion .
Protein Description	Catalyzes the conversion of monodehydroascorbate (MDA) to ascorbate, oxidizing NADH in the process. Can also use 2,4,6-trinitrotoluene (TNT) and 1-chloro-2,4-dinitrobenzene (CDNB) as substrates, but not 1-chloro-4-nitrobenzene (CNB)..
Protein Sequence	MSAVRRVMALASTTLPTKSGLSLWCPSSPSLARRFPARFSPIGSRIASRSLVTASFANENREFVIVGGGNAAGYAARTFVENGMADGRLCIVTKEAYAPYERPALTKAYLFPPEKKPARLPGFHTCVGGGGERQTPDWYKEKGIEVIYEDPVAGADFEKQTLTTDAGKQLKYGSLIIATGCTASRFPDKIGGHLPGVHYIREVADADSLIASLGKAKKIVIVGGGYIGMEVAAAAVAWNLDTTIVFPEDQLLQRLFTPSLAQKYEELYRQNGVKFVKGASINNLEAGSDGRVSAVKLADGSTIEADTVVIGIGAKPAIGPFETLAMNKSIGGIQVDGLFRTSTPGIFAIGDVAAFPLKIYDRMTRVEHVDHARRSAQHCVKSLLTAHTDTYDYLPYFYSRVFEYEGSPRKVWWQFFGDNVGETVEVGNFDPKIATFWIESGRLKGVLVESGSPEEFQLLPKLARSQPLVDKAKLASASSVEEALEIAQAALQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
208	Phosphorylation	REVADADSLIASLGK HHHCCHHHHHHHCCC	23776212
329	Phosphorylation	ETLAMNKSIGGIQVD HHHHCCCCCCCEEEE	30291188
407	Phosphorylation	RVFEYEGSPRKVWWQ HHEEECCCCCEEEEE	30291188
461	Acetylation	EEFQLLPKLARSQPL HHHCHHHHHHHCCCC	24727099
476	Phosphorylation	VDKAKLASASSVEEA CCHHHHCCCCCHHHH	23776212
478	Phosphorylation	KAKLASASSVEEALE HHHHCCCCCHHHHHH	23776212
479	Phosphorylation	AKLASASSVEEALEI HHHCCCCCHHHHHHH	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MDAR_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MDAR_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MDAR_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NIR_ARATH	NIR1	physical	21798944

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MDAR_ARATH

Related Literatures of Post-Translational Modification