MCTP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCTP2_HUMAN
• UniProt AC: Q6DN12
• Protein Name: Multiple C2 and transmembrane domain-containing protein 2
• Gene Name: MCTP2
• Organism: Homo sapiens (Human).
• Sequence Length: 878
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Might play a role in the development of cardiac outflow tract..
• Protein Sequence: MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEALAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDSEEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDLDKPSVWGSLKQ -CCCCCCCHHHHHHH	35.92	26074081
11	Phosphorylation	DKPSVWGSLKQRTRP CCCCHHHHHHHHHHC	19.38	28355574
13	Methylation	PSVWGSLKQRTRPLL CCHHHHHHHHHHCEE	39.16	115972899
24	Ubiquitination	RPLLINLSKKKVKKN HCEEEECCHHHHCCC	37.63	29967540
24	Phosphorylation	RPLLINLSKKKVKKN HCEEEECCHHHHCCC	37.63	25159151
27	Acetylation	LINLSKKKVKKNPSK EEECCHHHHCCCCCC	64.12	7674197
30	Acetylation	LSKKKVKKNPSKPPD CCHHHHCCCCCCCCC	76.66	7674207
33	Phosphorylation	KKVKKNPSKPPDLRA HHHCCCCCCCCCHHH	68.16	28464451
49	Phosphorylation	HHLDRRLSLSVPDLL HHHHHCCCCCHHHHH	19.45	26657352
51	Phosphorylation	LDRRLSLSVPDLLEA HHHCCCCCHHHHHHH	28.38	26657352
69	Phosphorylation	APEGRPYSGPQSSYT CCCCCCCCCCCCCCC	46.83	23898821
75	Phosphorylation	YSGPQSSYTSVPSSL CCCCCCCCCCCCCCC	14.31	27642862
76	Phosphorylation	SGPQSSYTSVPSSLS CCCCCCCCCCCCCCC	25.79	-
80	Phosphorylation	SSYTSVPSSLSTAGI CCCCCCCCCCCCCCC	41.58	-
94	Ubiquitination	IFPKSSSSSLKQSEE CCCCCCCCCHHHCHH	41.45	29967540
102	Ubiquitination	SLKQSEEELDWSQEE CHHHCHHHCCCCHHH	48.23	29967540
105	Ubiquitination	QSEEELDWSQEEASH HCHHHCCCCHHHHHC	17.97	29967540
111	Phosphorylation	DWSQEEASHLHVVET CCCHHHHHCCEEEEC	29.84	27642862
117	Ubiquitination	ASHLHVVETDSEEAY HHCCEEEECCCHHHC	45.89	29967540
118	Phosphorylation	SHLHVVETDSEEAYA HCCEEEECCCHHHCC	32.96	27642862
124	Phosphorylation	ETDSEEAYASPAERR ECCCHHHCCCHHHHC	15.76	27642862
134	Phosphorylation	PAERRRVSSNGIFDL HHHHCCCCCCCCEEE	19.10	23401153
135	Phosphorylation	AERRRVSSNGIFDLQ HHHCCCCCCCCEEEC	35.90	25159151
138	Ubiquitination	RRVSSNGIFDLQKTS CCCCCCCCEEECCCC	2.58	29967540
143	Ubiquitination	NGIFDLQKTSLGGDA CCCEEECCCCCCCCC	47.59	29967540
144	Phosphorylation	GIFDLQKTSLGGDAP CCEEECCCCCCCCCC	19.07	25159151
145	Phosphorylation	IFDLQKTSLGGDAPE CEEECCCCCCCCCCC	31.86	25159151
170	Ubiquitination	LNASMTSQHFEEQSV CCHHHHHHHHHHCCC	35.80	29967540
196	Ubiquitination	PSPFAYLLTIHLKEG CCHHHHEEEEEECCC	2.48	29967540
198	Ubiquitination	PFAYLLTIHLKEGRN HHHHEEEEEECCCCC	3.46	29967540
214	Phosphorylation	VVRDRCGTSDPYVKF EEECCCCCCCCEEEE	33.32	22210691
215	Phosphorylation	VRDRCGTSDPYVKFK EECCCCCCCCEEEEE	23.13	22210691
218	Phosphorylation	RCGTSDPYVKFKLNG CCCCCCCEEEEEECC	22.66	22210691
332	Phosphorylation	WSNRKRLSASKSSLI CCCCCCCCCCHHHHH	34.23	20873877
334	Phosphorylation	NRKRLSASKSSLIRN CCCCCCCCHHHHHHH	29.69	23312004
335	Acetylation	RKRLSASKSSLIRNL CCCCCCCHHHHHHHH	43.72	7668679
335	Ubiquitination	RKRLSASKSSLIRNL CCCCCCCHHHHHHHH	43.72	29967540
336	Phosphorylation	KRLSASKSSLIRNLR CCCCCCHHHHHHHHH	28.07	23312004
337	Phosphorylation	RLSASKSSLIRNLRL CCCCCHHHHHHHHHH	31.39	24719451
345	Phosphorylation	LIRNLRLSESLKKNQ HHHHHHHCHHHHHCC	20.78	25159151
347	Phosphorylation	RNLRLSESLKKNQLW HHHHHCHHHHHCCCC	41.96	28857561
350	Ubiquitination	RLSESLKKNQLWNGI HHCHHHHHCCCCCCE	56.04	-
374	Phosphorylation	NVSGGSMTEMFVQLK CCCCCCHHEEEEEEC	26.46	-
436	Ubiquitination	EERLGTCKVDISALP HHHHCCCCCCCCCCC	42.66	29967540
493	Phosphorylation	LSERKQITQRYCLQN HHHHHHHHHHHHHHH	12.42	24719451
496	Phosphorylation	RKQITQRYCLQNSLK HHHHHHHHHHHHHCC	6.41	24719451
506	Ubiquitination	QNSLKDVKDVGILQV HHHCCCCHHCCHHHH	57.75	29967540
514	Ubiquitination	DVGILQVKVLKAADL HCCHHHHEHHHHHHH	28.96	29967540
517	Ubiquitination	ILQVKVLKAADLLAA HHHHEHHHHHHHHHH	44.51	29967540
527	Phosphorylation	DLLAADFSGKSDPFC HHHHHCCCCCCCCEE	45.95	-
529	Ubiquitination	LAADFSGKSDPFCLL HHHCCCCCCCCEEEE	50.95	29967540
550	Ubiquitination	LQTHTVYKNLNPEWN CCEECEECCCCCHHH	51.10	29967540
582	Ubiquitination	VFDEDGDKPPDFLGK EECCCCCCCCCHHCC	65.07	29967540
608	Ubiquitination	QPNCYVLKNKDLEQA CCCEEEECCCCHHHH	52.48	29967540
610	Ubiquitination	NCYVLKNKDLEQAFK CEEEECCCCHHHHHC	63.20	29967540
730	Phosphorylation	RPVKGKVSSIQDSQE HCCCCCCCCCCCCCC	25.80	30108239
731	Phosphorylation	PVKGKVSSIQDSQES CCCCCCCCCCCCCCC	27.53	30108239
735	Phosphorylation	KVSSIQDSQESTDID CCCCCCCCCCCCCCC	21.33	26657352
738	Phosphorylation	SIQDSQESTDIDDEE CCCCCCCCCCCCCCC	24.60	30108239
739	Phosphorylation	IQDSQESTDIDDEED CCCCCCCCCCCCCCC	35.90	23401153
752	Phosphorylation	EDEDDKESEKKGLIE CCCCCHHHHHHHHHH	61.53	25841592
801	Ubiquitination	PFLSSLACLILAAAT HHHHHHHHHHHHHHH	2.70	29967540
818	Phosphorylation	LYFIPLRYIILIWGI HHHHHHHHHHHHHCH	10.45	-
856	Ubiquitination	RVPSDVQKVQYAELK CCCCCHHHHHHHHHH	31.02	29967540
866	Phosphorylation	YAELKLCSSHSPLRK HHHHHHHHCCCCHHH	41.33	30108239
867	Phosphorylation	AELKLCSSHSPLRKK HHHHHHHCCCCHHHH	27.30	30108239
869	Phosphorylation	LKLCSSHSPLRKKRS HHHHHCCCCHHHHHH	27.81	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCTP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCTP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCTP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-144 AND SER-145, ANDMASS SPECTROMETRY.
PubMed: 17924679