MBD7_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBD7_ARATH
• UniProt AC: Q9FJF4
• Protein Name: Methyl-CpG-binding domain-containing protein 7 {ECO:0000303|PubMed:12954765}
• Gene Name: MBD7 {ECO:0000303|PubMed:12954765}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 306
• Subcellular Localization: Nucleus . Chromosome . Associated with heterochromatin, at all chromocenters. Excluded from nucleolus.
• Protein Description: Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression. [PubMed: 25684209 Requires high mCG density for binding]
• Protein Sequence: MQTRSSSSPSANHRRETQLQIADPTSFCGKIMPGWTVVNRPRSSNNGVVDTYFIEPGTGRQFSSLEAIHRHLAGEVNDRRLTRAGSFFQDKTRVYEGSRTKQDHCGVEYASKGFRLPRGWSVEEVPRKNSHYIDKYYVERKTGKRFRSLVSVERYLRESRNSIEQQLRVLQNRRGHSKDFRLPDGWIVEEKPRRSSSHIDRSYIEPGTGNKFRSMAAVERYLISVGNITLDSVSMVHSERLPLLMNRNGIRFQSEVIDPNPPKKVKWVLTGSGGNMFTANVRGSNVSSLVKHTWSEAFVSLIEDRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	RRLTRAGSFFQDKTR HHHHCCCCHHCCCCC	23.15	25561503
118	Asymmetric dimethylarginine	SKGFRLPRGWSVEEV CCCCCCCCCCCCCCC	64.90	-
118	Methylation	SKGFRLPRGWSVEEV CCCCCCCCCCCCCCC	64.90	17711414
145	Asymmetric dimethylarginine	VERKTGKRFRSLVSV EEECCCCCHHHHHHH	33.29	-
145	Methylation	VERKTGKRFRSLVSV EEECCCCCHHHHHHH	33.29	17711414
174	Asymmetric dimethylarginine	LRVLQNRRGHSKDFR HHHHHHCCCCCCCCC	55.51	-
174	Methylation	LRVLQNRRGHSKDFR HHHHHHCCCCCCCCC	55.51	17711414

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBD7_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBD7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBD7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM11_ARATH	PRMT11	physical	17711414

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.