| UniProt ID | MAEL_DROME | |
|---|---|---|
| UniProt AC | Q9VNS0 | |
| Protein Name | Protein maelstrom | |
| Gene Name | mael | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 459 | |
| Subcellular Localization | Cytoplasm. Nucleus . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Vas, aub and spn-E are required for nuage localization. Shuttles between the cytoplasm a | |
| Protein Description | Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage. Indirectly required to position the microtubule organizing center in stage 2-6 oocytes.. | |
| Protein Sequence | MAPKKHSGFMMFVNEWRNRNAEGRRMTLAQAVSHCGTIWEKMNTQQRGPYNSGGKDANVAQRAKRESSNGHGQVDKAQREATESLMDMKRTIERLVLNAKMSHDLENAKFVFVAFNYFTKALTTDVYVPAEFAACEYSLKEGIRSIYSTMIDPGQIIFGQGSDALLHSSTTHDLPLPPNALGEKNMTKLYRNIVDYLSKCQGKGKTLVVFTPAENITMVKSCFRYLECDDDFRDGGEKIQVFDIQYLLFILKKEVMNVADLNDEKINKFATDAFFKKDFFEFTAGIACQYHEDNDRTKYCTQSMVTRWAYTFTDFMCGDLAITVQPGKHIPAQTKPNYLIISSYASSLDHESSFDSFYSLPGSGVKKESQPEACSLSSSRLSVASSSYKPIDHTSFAANLNEVSEFPSLGMRNSSKHHGIAASAQREWNARNLPTHSRLIRKVSDNDFSVNGADGKLKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Phosphorylation | MTLAQAVSHCGTIWE CHHHHHHHHHHHHHH | 18.97 | 21082442 | |
| 67 | Phosphorylation | AQRAKRESSNGHGQV HHHHHHHHCCCCCCC | 32.89 | 19429919 | |
| 68 | Phosphorylation | QRAKRESSNGHGQVD HHHHHHHCCCCCCCC | 41.92 | 19429919 | |
| 444 | Phosphorylation | SRLIRKVSDNDFSVN HHHHHHHCCCCCCCC | 33.46 | 19429919 | |
| 449 | Phosphorylation | KVSDNDFSVNGADGK HHCCCCCCCCCCCCC | 19.96 | 25749252 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAEL_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAEL_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAEL_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ERKA_DROME | rl | physical | 14605208 | |
| KLC_DROME | Klc | genetic | 24531791 | |
| DCR1_DROME | Dcr-1 | genetic | 19758565 | |
| BAM_DROME | bam | genetic | 19758565 | |
| TBG1_DROME | gammaTub23C | physical | 22085963 | |
| TBG2_DROME | gammaTub37C | physical | 22085963 | |
| CNN_DROME | cnn | physical | 22085963 | |
| POLO_DROME | polo | physical | 23136393 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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