LT4R2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LT4R2_HUMAN
• UniProt AC: Q9NPC1
• Protein Name: Leukotriene B4 receptor 2
• Gene Name: LTB4R2
• Organism: Homo sapiens (Human).
• Sequence Length: 389
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3..
• Protein Sequence: MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	N-linked_Glycosylation	PSHRASQVGFCPTPE CCCCCCCCCCCCCCC	6.17	-
41	N-linked_Glycosylation	VCYRPPGNETLLSWK EEECCCCCCEEEECH	44.87	UniProtKB CARBOHYD
129	Phosphorylation	QAGCKAVYYVCALSM HHHHHHHHHHHHHHH	8.61	-
147	Phosphorylation	VLLTGLLSLQRCLAV HHHHHHHHHHHHHHH	27.74	24719451
215	Phosphorylation	HAAAHLSLETLTAFV HHHHHCCHHHHHHHH	7.99	24719451
246	Phosphorylation	LRGARWGSGRHGARV HCCCCCCCCCCHHHH	26.20	24719451
311	Phosphorylation	TTALAFFSSSVNPVL CHHHHHHCCCCCCEE	18.43	24719451
324	Phosphorylation	VLYVFTAGDLLPRAG EEEEEEHHHCCCCCC	24.04	-
336	Phosphorylation	RAGPRFLTRLFEGSG CCCHHHHHHHCCCCC	23.71	-
342	Phosphorylation	LTRLFEGSGEARGGG HHHHCCCCCCCCCCC	26.68	24719451
355	Phosphorylation	GGRSREGTMELRTTP CCCCCCCEEEEECCC	11.61	22044535
361	Phosphorylation	GTMELRTTPQLKVVG CEEEEECCCCEEEEE	11.56	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
324	T	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LT4R2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LT4R2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RANB9_HUMAN	RANBP9	physical	23928309
LT4R2_HUMAN	LTB4R2	physical	20026606

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D04074: Etalocib (USAN)
• D05085: Moxilubant maleate (USAN)
• D06140: Ticolubant (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.