LSD1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSD1_DROME
• UniProt AC: Q9VCI3
• Protein Name: Lipid storage droplets surface-binding protein 1
• Gene Name: Lsd-1 {ECO:0000312|EMBL:AAF56183.2}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 431
• Subcellular Localization: Cytoplasm . Lipid droplet . Cytoplasmic and in lipid storage droplets of adipocytes of first instar larvae. Colocalizes with Lsd-2 on the surface of neutral lipid storage droplets in cells of fat bodies.
• Protein Description: Required for normal deposition of neutral lipids in the oocyte..
• Protein Sequence: MATATSGSGLHLEAIDRIGSIPLVESSVKRVETIYDKVKNNNRLFSWYFETAEATISAAYETIQPAVKLFEPSIQRLDNVMCKSLDILEQRIPLVYLPPEMMYWNTKEYMSDHLVRPVLKRADSVKQIGNAVLESPLTTYAAERIDGAFTVGDKFVDKYLVPIQTDQDQTDVKKLVSALNDNFSPIRQQLNRMFGHKSPQEDDNEAVPDERGAIKAIHHGQRFSRKLKRRLTQRTIAEARALKKQSKEAIHVLFYAAELIATDPKQAVQKAKELWVYLSADEPENQARPATLEQLIVLLTRESARRVVHLVNFSAHVAANIPRNLAHTTTEVAHHIIYINHRIITISRLDKVKTISKEEAESLFKRMLAFYGSLQGLTNAYLERVASFLSGRMEAEKVTGSDGGNSNHRSSRRRQDPNHYSATHNNINGVY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MATATSGSGLHLE --CCCCCCCCCCCHH	28.62	27794539
8	Phosphorylation	MATATSGSGLHLEAI CCCCCCCCCCCHHHH	37.64	27794539
20	Phosphorylation	EAIDRIGSIPLVESS HHHHHHCCCCCCHHH	20.75	18342616

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
20	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
20	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSD1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSD1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LSD2_DROME	Lsd-2	genetic	22505614
DIAP1_DROME	th	genetic	27136547

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.