LMTK3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMTK3_HUMAN
• UniProt AC: Q96Q04
• Protein Name: Serine/threonine-protein kinase LMTK3
• Gene Name: LMTK3
• Organism: Homo sapiens (Human).
• Sequence Length: 1460
• Subcellular Localization: Membrane ; Single-pass membrane protein . Cell projection, axon . Cell projection, dendrite . Golgi apparatus membrane . Punctate pattern in cell projections.
• Protein Description: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. [PubMed: 21602804 Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity]
• Protein Sequence: MPAPGALILLAAVSASGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	LGEIFSDYTPAQVVV HHHHHCCCCHHHHHH	17.27	18083107
169	Phosphorylation	VVKELRASAGPLEQR HHHHHHHCCCHHHHH	27.59	22985185
198	Phosphorylation	PNVLQCLGLCVETLP CCHHHHHHHHHHHHH	25.34	27251275
232	Phosphorylation	QRPPEGLSPELPPRD CCCCCCCCCCCCHHH	27.47	24076635
296	Phosphorylation	HSNYKEDYYLTPERL CCCCCCCCCCCHHHC	11.06	-
297	Phosphorylation	SNYKEDYYLTPERLW CCCCCCCCCCHHHCE	19.20	-
490	Methylation	KARRGAGRGGGAPAW HHHHCCCCCCCCCCC	39.80	16187427
531	Phosphorylation	LPVISARSPSVSSEY CCEEECCCCCCCCEE	22.65	24076635
535	Phosphorylation	SARSPSVSSEYYIRL ECCCCCCCCEEEEEH	23.07	-
908	Phosphorylation	PGLNRDPTVLGNGKQ CCCCCCCCCCCCCCC	32.43	-
951	Phosphorylation	AENGALGSPEREEKV HHHCCCCCHHHHHHH	25.16	25332170
981	Phosphorylation	LENGELRSPEAGEKV HHCCCCCCCCCCCCE	39.45	25307156
995	Phosphorylation	VLVNGGLTPPKSEDK EEECCCCCCCCCCCC	40.60	-
1004	Phosphorylation	PKSEDKVSENGGLRF CCCCCCCCCCCCCCC	30.96	24114839
1080	Acetylation	GPLGPAPKNGTLEPG CCCCCCCCCCCCCCC	70.84	18586811
1081	N-linked_Glycosylation	PLGPAPKNGTLEPGT CCCCCCCCCCCCCCC	47.85	UniProtKB CARBOHYD
1111	Phosphorylation	AGRLDLGSGGRAPVG CCCCCCCCCCCCCCC	45.42	25072903
1119	Phosphorylation	GGRAPVGTGTAPGGG CCCCCCCCCCCCCCC	31.43	25072903
1121	Phosphorylation	RAPVGTGTAPGGGPG CCCCCCCCCCCCCCC	29.53	25072903
1129	Phosphorylation	APGGGPGSGVDAKAG CCCCCCCCCCCCCCC	38.48	25072903
1141	Phosphorylation	KAGWVDNTRPQPPPP CCCCCCCCCCCCCCC	38.98	25072903
1183	Phosphorylation	GEPGAPDSRAGGDTA CCCCCCCCCCCCCCC	23.99	-
1241	Phosphorylation	ALPPLTLTPFPGPGP CCCCCCCCCCCCCCC	20.04	-
1316	O-linked_Glycosylation	APVPVVVSSADADAA CCCCEEEECCCHHHH	14.27	28657654
1405	N-linked_Glycosylation	PGDGFPSNDSGFGGS CCCCCCCCCCCCCCC	47.94	UniProtKB CARBOHYD
1432	Phosphorylation	PGPPLCFSRFSVSPA CCCCCCCCCEEECCC	31.27	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMTK3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMTK3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMTK3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT16_HUMAN	ZBTB16	physical	16169070

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.