LIPA_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPA_CAEEL
• UniProt AC: Q21049
• Protein Name: Liprin-alpha
• Gene Name: syd-2
• Organism: Caenorhabditis elegans.
• Sequence Length: 1139
• Subcellular Localization: Cell junction, synapse . Presynaptic region.
• Protein Description: May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse..
• Protein Sequence: MSYSNGNINCDIMPTISEDGVDNGGPIDEPSDRDNIEQLMMNMLEDRDKLQEQLENYKVQLENAGLRTKEVEKERDMMKRQFEVHTQNLPQELQTMTRELCLLKEQLLEKDEEIVELKAERNNTRLLLEHLECLVSRHERSLRMTVMKRQAQNHAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVAMERVATLEEELSTKGDENSSLKARIATYAAEAEEAMASNAPINGSISSESANRLIEMQEALERMKTELANSLKQSTEITTRNAELEDQLTEDAREKHAAQESIVRLKNQICELDAQRTDQETRITTFESRFLTAQRESTCIRDLNDKLEHQLANKDAAVRLNEEKVHSLQERLELAEKQLAQSLKKAESLPSVEAELQQRMEALTAAEQKSVSAEERIQRLDRNIQELSAELERAVQRERMNEEHSQRLSSTVDKLLSESNDRLQLHLKERMQALDDKNRLTQQLDGTKKIYDQAERIKDRLQRDNESLRQEIEALRQQLYNARTAQFQSRMHAIPFTHAQNIVQQQPQASIAQQSAYQMYKQQPAQQYQTVGMRRPNKGRISALQDDPNKVQTLNEQEWDRLQQAHVLANVQQAFSSSPSLADVGQSTLPRPNTAVQHQQDDMMNSGMGMPSGMQGGMQGGMGGGQDAQMLASMLQDRLDAINTEIRLIQQEKHHAERVAEQLERSSREFYDDQGISTRSSPRASPQLDNMRQHKYNTLPANVSGDRRYDIYGNPQFVDDRMVRDLDYEPRRGYNQFDEMQYERDRMSPASSVASSTDGVLGGKKKRSNSSSGLKTLGRFFNKKKNSSSDLFKRNGDYSDGEQSGTEGNQKADYDRRKKKKHELLEEAMKARTPFALWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMSALSDQEIQKEIGISNPLHRLKLRLAIQEMVSLTSPSAPRTARLTLAFGDMNHEYIGNDWLPCLGLAQYRSAFMECLLDARMLEHLSKRDLRTHLRMVDTFHRTSLQYGIMCLKKVNYDKKVLADRRKACDNINTDLLVWSNERVQRWVEEIGLGVFSRNLVDSGIHGALIALDETFDASAFAYALQIGSQDVPNRQLLEKKFIGLVNDHRQQSDPHPRSGSSRKNDSIAKSYEFHLYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
582	Phosphorylation	DDPNKVQTLNEQEWD CCCCHHHCCCHHHHH	34.24	19530675
709	Phosphorylation	DQGISTRSSPRASPQ CCCCCCCCCCCCCCC	44.79	21082442
710	Phosphorylation	QGISTRSSPRASPQL CCCCCCCCCCCCCCH	18.34	21082442
714	Phosphorylation	TRSSPRASPQLDNMR CCCCCCCCCCHHCCH	17.92	19060867
741	Phosphorylation	GDRRYDIYGNPQFVD CCCCEECCCCCCCCC	14.14	27067626
816	Phosphorylation	FFNKKKNSSSDLFKR HHCCCCCCCCHHHHH	39.85	28854356
817	Phosphorylation	FNKKKNSSSDLFKRN HCCCCCCCCHHHHHC	36.95	30078680
818	Phosphorylation	NKKKNSSSDLFKRNG CCCCCCCCHHHHHCC	37.85	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPA_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPA_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPA_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIPA_CAEEL	syd-2	physical	22072677

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.