LIPA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPA4_HUMAN
• UniProt AC: O75335
• Protein Name: Liprin-alpha-4
• Gene Name: PPFIA4
• Organism: Homo sapiens (Human).
• Sequence Length: 1185
• Subcellular Localization: Cytoplasm. Cell surface. Colocalizes with PTPRF at the cell surface..
• Protein Description: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity)..
• Protein Sequence: MCEVMPTINEGDRLGPPHGADADANFEQLMVNMLDEREKLLESLRESQETLAATQSRLQDAIHERDQLQRHLNSALPQEFATLTRELSMCREQLLEREEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRAALERVTTLEEQLAGAHQQVSALQQGAGVRDGAAEEEGTVELGPKRLWKEDTGRVEELQELLEKQNFELSQARERLVTLTTTVTELEEDLGTARRDLIKSEELSSKHQRDLREALAQKEDMEERITTLEKRYLAAQREATSIHDLNDKLENELANKESLHRQCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEEHLRQLEGQLEEKNQELARTAVQVRQREKMNEDHNKRLSDTVDRLLSESNERLQLHLKERMAALEEKNTLIQELESSQRQIEEQHHHKGRLSEEIEKLRQEVDQLKGRGGPFVDGVHSRSHMGSAADVRFSLGTTTHAPPGVHRRYSALREESAKLALPLTVTLRSPTWMRMSQGVCCNLEYHSSGTLCGSSGPLPVPEMIQEEKESTELRAEEIETRVTSGSMEALNLKQLRKRGSIPTSLTALSLASASPPLSGRSTPKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDKATIKCETSPPSSPRTLRLEKLGHPALSQEEGKSALEDQGSNPSSSNSSQDSLHKGAKRKGIKSSIGRLFGKKEKGRLIQLSRDGATGHVLLTDSEFSMQEPMVPAKLGTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLETSTKTDSEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLALILQIPTQNTQARQVMEREFNNLLALGTDRKLDDGDDKVFRRAPSWRKRFRPREHHGRGGMLSASAETLPAGFRVSTLGTLQPPPAPPKKIMPEAHSHYLYGHMLSAFRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	LVSRHERSLRMTVVK HHHHCHHHHHEEEEE	17.14	-
140	Phosphorylation	VVKRQAQSPSGVSSE EEEHHCCCCCCCCHH	37.34	24076635
142	Phosphorylation	KRQAQSPSGVSSEVE EHHCCCCCCCCHHHH	29.45	24076635
145	Phosphorylation	AQSPSGVSSEVEVLK CCCCCCCCHHHHHHH	34.40	-
212	Phosphorylation	GAAEEEGTVELGPKR CCCCCCCCEECCCCC	22.97	-
216	Phosphorylation	EEGTVELGPKRLWKE CCCCEECCCCCCCCC	16.72	18669648
220	Phosphorylation	VELGPKRLWKEDTGR EECCCCCCCCCCCCH	24.95	18669648
251	Phosphorylation	QARERLVTLTTTVTE HHHHHHHHHHHHHHH	51.12	28111955
253	Phosphorylation	RERLVTLTTTVTELE HHHHHHHHHHHHHHH	45.10	28111955
254	Phosphorylation	ERLVTLTTTVTELEE HHHHHHHHHHHHHHH	47.86	28111955
255	Phosphorylation	RLVTLTTTVTELEED HHHHHHHHHHHHHHH	31.18	28111955
257	Phosphorylation	VTLTTTVTELEEDLG HHHHHHHHHHHHHHC	44.10	28111955
363	Phosphorylation	QTMRKAETLPEVEAE HHHHHHCCCHHHHHH	5.14	30624053
436	Phosphorylation	DTVDRLLSESNERLQ HHHHHHHHHCHHHHH	28.69	28348404
438	Phosphorylation	VDRLLSESNERLQLH HHHHHHHCHHHHHHH	48.40	28348404
513	Phosphorylation	HSRSHMGSAADVRFS CCCCCCCCCCCEEEE	17.27	25404012
520	Phosphorylation	SAADVRFSLGTTTHA CCCCEEEEECCCCCC	3.71	22468782
523	Phosphorylation	DVRFSLGTTTHAPPG CEEEEECCCCCCCCC	18.41	25404012
524	Phosphorylation	VRFSLGTTTHAPPGV EEEEECCCCCCCCCH	7.14	25404012
525	Phosphorylation	RFSLGTTTHAPPGVH EEEECCCCCCCCCHH	40.46	25404012
535	Phosphorylation	PPGVHRRYSALREES CCCHHHHHHHHHHHH	64.20	22468782
536	Phosphorylation	PGVHRRYSALREESA CCHHHHHHHHHHHHH	67.06	26437602
609	O-linked_Glycosylation	EEIETRVTSGSMEAL HHHHHHHCCCCHHHH	35.39	30379171
610	Phosphorylation	EIETRVTSGSMEALN HHHHHHCCCCHHHHC	39.15	28857561
640	Phosphorylation	ALSLASASPPLSGRS HHHHHCCCCCCCCCC	25.00	24076635
667	Phosphorylation	LDRMGVMTLPSDLRK HHHCCCCCCCHHHHH	17.41	29759185
670	Phosphorylation	MGVMTLPSDLRKHRR CCCCCCCHHHHHHHH	25.19	27732954
681	Phosphorylation	KHRRKLLSPVSREEN HHHHHHCCCCCCCCC	50.43	23312004
684	Phosphorylation	RKLLSPVSREENRED HHHCCCCCCCCCCCC	38.81	26437602
699	Phosphorylation	KATIKCETSPPSSPR CCEEECCCCCCCCCC	8.96	29255136
700	Phosphorylation	ATIKCETSPPSSPRT CEEECCCCCCCCCCE	48.74	29255136
703	Phosphorylation	KCETSPPSSPRTLRL ECCCCCCCCCCEEEH		29255136
704	Phosphorylation	CETSPPSSPRTLRLE CCCCCCCCCCEEEHH		29255136
740	Phosphorylation	NPSSSNSSQDSLHKG CCCCCCCCHHHHHHH		22817900
751	Acetylation	LHKGAKRKGIKSSIG HHHHHHHHCCHHHHH		130845
754	Acetylation	GAKRKGIKSSIGRLF HHHHHCCHHHHHHHH		130847
755	Phosphorylation	AKRKGIKSSIGRLFG HHHHCCHHHHHHHHC		21712546
756	Phosphorylation	KRKGIKSSIGRLFGK HHHCCHHHHHHHHCC		21712546
786	Phosphorylation	GHVLLTDSEFSMQEP CEEEECCCCCCCCCC		22210691
789	Phosphorylation	LLTDSEFSMQEPMVP EECCCCCCCCCCCCC		22210691
866	Phosphorylation	GAIMSALSDTEIQRE CCHHHHCCCHHHHHH		-
897	Phosphorylation	QEMVSLTSPSAPPTS HHHHHCCCCCCCCCC		25307156
992	Phosphorylation	VHLKMVDSFHRTSLQ HHHHHHHCCHHHHHH		28857561
1103	Phosphorylation	NNLLALGTDRKLDDG HHHHHHCCCCCCCCC		-
1120	Phosphorylation	KVFRRAPSWRKRFRP CCHHCCCHHHHHCCC		25394399
1133	Methylation	RPREHHGRGGMLSAS CCCCCCCCCCCCCCC		115482179
1151	Phosphorylation	LPAGFRVSTLGTLQP CCCCEEEEECCCCCC		-
1152	Phosphorylation	PAGFRVSTLGTLQPP CCCEEEEECCCCCCC		-
1181	Phosphorylation	YLYGHMLSAFRD--- HHHHHHHHHHCC---		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERC2_HUMAN	ERC2	physical	12923177
GIT1_HUMAN	GIT1	physical	12923177
GIT1_HUMAN	GIT1	physical	12629171
NCOA2_HUMAN	NCOA2	physical	11931740

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.