dbPTM

LIN44_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LIN44_CAEEL
UniProt AC	Q27886
Protein Name	Abnormal cell lineage protein 44
Gene Name	lin-44 {ECO:0000312\|EMBL:AAA64847.1, ECO:0000312\|WormBase:E01A2.3a}
Organism	Caenorhabditis elegans.
Sequence Length	348
Subcellular Localization	Secreted, extracellular space, extracellular matrix .
Protein Description	Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis..
Protein Sequence	MRAAPFDFFFQSTALSTFFILCSLATNEIPTISGAPAGKIVQPPKPNILKQGCPSDLLHSRALRSIQLACRTHPATVISAFEGVQEGLQNCANRLRFQQWDCSEAGNIMHDPPLLRQGFRESSLIWALSSASAAWGVATACAQGWIDDCACNNQMGQNEYEFGGCTHGVQHGITASRKLLTKVGAVNTLLRKVEKHNLKAGRLAIKKTLISSCKCHGVSGSCQQKTCWKRTATLEHITDYLVEKYARAKLYTDDSVVKTTDLIYLEASPDVCKAKSVAGRVCAWRNETHTQGDCDRLCCGNGFSIRHEVVRVKCDCEFVWCCNLVCKDCIQHRWISTCNGTPPKSLIF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
219	O-palmitoleoylation	SCKCHGVSGSCQQKT HCCCCCCCCCCCCCC	29.58	-
286	N-linked_Glycosylation	GRVCAWRNETHTQGD CCEECCCCCCCCCCC	48.06	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LIN44_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LIN44_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LIN44_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NLK_CAEEL	lit-1	genetic	10380924

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LIN44_CAEEL

Related Literatures of Post-Translational Modification