LET99_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LET99_CAEEL
• UniProt AC: Q21341
• Protein Name: Protein let-99
• Gene Name: let-99
• Organism: Caenorhabditis elegans.
• Sequence Length: 698
• Subcellular Localization: Cytoplasm . Cytoplasm, cell cortex . Enriched at the cell cortex during both meiosis and mitosis (PubMed:12223405). Enriched asymmetrically at the cell cortex in 1-cell embryos (PubMed:14534135). Localizes at the contact site between EMS and P2 in in
• Protein Description: Required for the proper orientation of spindles after the establishment of polarity. [PubMed: 9477332]
• Protein Sequence: MSADYSSEKFKATHLFDEILWHFRSNLSLKTNRRGLATAENSFSGKEAVDFLMIEMPRIIPNNVPERDKMQKFLEFMMDMNVISEAFPKKVKQRRPFSESRIYLFMKTLDELKHPKPRSRRSASFSGARKSAKVAQPASPAATMHRPPKARLPRRLSRSNGNIDKAGIDNSSGGVENHGFDDHKDDEIPKKQRTPKILNRSLESICTEEYTEKREVSEMKEKVYDWLPFFKSRRNHTKVNQPTRRSASLDRNHCVLEQEKAEAALRSQKVTTPPIREAPKDVVFMHPQGPLPAVPSRYQNHRTSIAGSNPALLSRGRMYESIMRRSSVVPVADSVQANNECSFWKTELLGRLEQIYDRTLPCEWASKVDGYDIQWNMIEIDHADGIVKSRCQGLQPDYPQTVIQFMDYLVRYPFVTHKKMDTGLEYNVNRIFITLVNRLEDLNAPLQFDECSLIVNLLCKIDSFAAMLDNGPARRWSKVMISSSASSIEEAGLMVDGFSRDLPACGIRASKYRRRALSPFDNRVNLEIQDEKSYEIREQWLIEAIQLVLLSLPTSRRRKLHKFVTFIQSIETNAVFDLADPSNGSSNNREAAIIGLWTGVCSKCRKQQGMLITAVLLANFQSLFAVPVEFIEQVKRLECEEKDRYSGPRYAKITRSRNDWQPPVPDKPQASPAVFKKPLREVACEKTKKGLFTRLLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
124	Phosphorylation	PRSRRSASFSGARKS CCCCCCCCCCCCHHH	22.61	30078680
139	Phosphorylation	AKVAQPASPAATMHR CCCCCCCCCHHHCCC	23.04	30078680
224	Phosphorylation	SEMKEKVYDWLPFFK HHHHHHHHHHHHHHH	16.69	27067626
518	Phosphorylation	KYRRRALSPFDNRVN HHHHHCCCCCCCCCC	23.65	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LET99_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LET99_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LET99_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIN41_CAEEL	lin-41	physical	18692475
COPB2_CAEEL	copb-2	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.