COPB2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPB2_CAEEL
• UniProt AC: Q20168
• Protein Name: Probable coatomer subunit beta'
• Gene Name: copb-2
• Organism: Caenorhabditis elegans.
• Sequence Length: 1000
• Subcellular Localization: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)..
• Protein Sequence: MPLRLDVKRKLLARSDRVKCVDLHPVETWLLAALYNGNVHIWNYETQTLVKSFEVCDVPVRAAKFVPRKSWVVTGSDDMHIRVFNYNTLERVHQFEAHSDYLRSLVVHPTLPYVISSSDDMLVKMWDWDNKWAMKQSFEGHTHYVMQIAINPKDNNTFATASLDKTVKVWQFGSNVPNFTLEGHEKGVNCVDYYHGGEKPYIISGADDHLVKIWDYQNKTCVQTLDGHAQNVSSVCFHPELPLIITGSEDSTVRLWHANTYRLETTLNYGLERVWCIQAQKGANTIAIGYDEGSVTLKLGREEPAVSMDSSGKILWAKHSEIQQANLKTISTEESEAIQDGERLPLSVKDLGSSEIYPQTLAHSSNGRFVVACGDGEYIVYTAMALRNKDFGQGLEFVWAVDPNMFAVRESATNVKIKKNFKDHKSIRSDMVLEGISGGPLLALRSNNSLCFFDWESAVLVRRIEITSKSIYWSDNGEMVAICGDDSFYVLKYSAEAVANATEVTEDGIEDAFEVIGEQAEAVKTGFWIGDCFIFTTALNRINYYVGGEIVTIAHVDRPLYLLGYMAKESRVYAVDKDLNVISYKLLLSVLEYQTAVMRRDFDTADKVLTTIPKEQRTRVAHFLEKQGFKKQALAVSQDPDHKFDLSVALGDLKTAYDLALQSDSEEKWKALSNAATLKSELLLAGECLGRARDFGGLMLLATCAGSAPLLQKLADDSAAAESHNISFLSSLLLGDIDACLDKLISTGRLPEAAFLARTHAPSRVSSILELWKAKASGHSEKSSRKIGESLADPVKYENLFPGFTQSLKAESFVREISKIPVPASVRVPSAATRNIQEELDEAVASGAVSFTDDGQAVLKNAPRQTETQLKAPPPPSVARQPSPVRQPSPIREPSPIREPEPEEEEEQEEFDDDQQEVHVPANQESADAHGTSKTPDVVLETSRPDIVPPRGSAAPDLVSASSQQSAQDFQDDTQWSDEDFGDAENGDLNMDDLNLDEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
429	Phosphorylation	KDHKSIRSDMVLEGI CCCCCCCCCCEEECC	28.52	19530675
767	Phosphorylation	HAPSRVSSILELWKA CCCHHHHHHHHHHHH	28.47	28854356
935	Phosphorylation	DAHGTSKTPDVVLET HCCCCCCCCCEEEEC	25.21	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPB2_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPB2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPB2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.