LEP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEP_HUMAN
• UniProt AC: P41159
• Protein Name: Leptin {ECO:0000312|HGNC:HGNC:6553}
• Gene Name: LEP {ECO:0000312|HGNC:HGNC:6553}
• Organism: Homo sapiens (Human).
• Sequence Length: 167
• Subcellular Localization: Secreted .
• Protein Description: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. [PubMed: 17344214]
• Protein Sequence: MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	RINDISHTQSVSSKQ HHHHCCCCCCCCCCC	18.75	-
54	Sulfoxidation	HTQSVSSKQKVTGLD CCCCCCCCCCCCCCC	46.78	9587962
68	Sulfoxidation	DFIPGLHPILTLSKM CCCCCCCHHHHHHHH	28.47	9587962
114	Phosphorylation	LLHVLAFSKSCHLPW HHHHHHHCCCCCCCC	20.32	28102081
136	Sulfoxidation	DSLGGVLEASGYSTE HHHCCHHHHCCCCHH	38.08	9587962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HXK3_RAT	Hk3	physical	11068878

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.