LAD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAD1_HUMAN
• UniProt AC: O00515
• Protein Name: Ladinin-1
• Gene Name: LAD1
• Organism: Homo sapiens (Human).
• Sequence Length: 517
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Anchoring filament protein which is a component of the basement membrane zone..
• Protein Sequence: MAVSRKDWSALSSLARQRTLEDEEEQERERRRRHRNLSSTTDDEAPRLSQNGDRQASASERLPSVEEAEVPKPLPPASKDEDEDIQSILRTRQERRQRRQVVEAAQAPIQERLEAEEGRNSLSPVQATQKPLVSKKELEIPPRRRLSREQRGPWALEEESLVGREPEERKKGVPEKSPVLEKSSMPKKTAPEKSLVSDKTSISEKVLASEKTSLSEKIAVSEKRNSSEKKSVLEKTSVSEKSLAPGMALGSGRRLVSEKASIFEKALASEKSPTADAKPAPKRATASEQPLAQEPPASGGSPATTKEQRGRALPGKNLPSLAKQGASDPPTVASRLPPVTLQVKIPSKEEEADMSSPTQRTYSSSLKRSSPRTISFRMKPKKENSETTLTRSASMKLPDNTVKLGEKLERYHTAIRRSESVKSRGLPCTELFVAPVGVASKRHLFEKELAGQSRAEPASSRKENLRLSGVVTSRLNLWISRTQESGDQDPQEAQKASSATERTQWGQKSDSSLDAEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RKDWSALSSLARQRT HHHHHHHHHHHHHCC	24.03	28355574
13	Phosphorylation	KDWSALSSLARQRTL HHHHHHHHHHHHCCC	27.22	28857561
19	Phosphorylation	SSLARQRTLEDEEEQ HHHHHHCCCCCHHHH	26.59	27273156
38	Phosphorylation	RRRHRNLSSTTDDEA HHHHHCCCCCCCCCC	29.23	27273156
39	Phosphorylation	RRHRNLSSTTDDEAP HHHHCCCCCCCCCCC	38.19	27273156
40	Phosphorylation	RHRNLSSTTDDEAPR HHHCCCCCCCCCCCC	30.76	23927012
41	Phosphorylation	HRNLSSTTDDEAPRL HHCCCCCCCCCCCCC	43.32	23927012
49	Phosphorylation	DDEAPRLSQNGDRQA CCCCCCCCCCCCCCC	23.91	28985074
57	Phosphorylation	QNGDRQASASERLPS CCCCCCCCHHHCCCC	24.80	25394399
59	Phosphorylation	GDRQASASERLPSVE CCCCCCHHHCCCCHH	22.28	26657352
64	Phosphorylation	SASERLPSVEEAEVP CHHHCCCCHHHCCCC	46.91	28355574
78	Phosphorylation	PKPLPPASKDEDEDI CCCCCCCCCCCCHHH	46.54	22798277
87	Phosphorylation	DEDEDIQSILRTRQE CCCHHHHHHHHHHHH	24.75	24719451
121	Phosphorylation	EAEEGRNSLSPVQAT HHHCCCCCCCCCCCC	28.94	30278072
123	Phosphorylation	EEGRNSLSPVQATQK HCCCCCCCCCCCCCC	23.89	28355574
128	Phosphorylation	SLSPVQATQKPLVSK CCCCCCCCCCCCCCH	21.75	23927012
134	Phosphorylation	ATQKPLVSKKELEIP CCCCCCCCHHHHCCC	45.77	23927012
147	Phosphorylation	IPPRRRLSREQRGPW CCCCCCCCHHHCCCC	31.77	23312004
160	Phosphorylation	PWALEEESLVGREPE CCHHHHHHHCCCCHH	31.47	27251275
177	Phosphorylation	KKGVPEKSPVLEKSS HCCCCCCCCCCCCCC	20.69	30278072
184	Phosphorylation	SPVLEKSSMPKKTAP CCCCCCCCCCCCCCC	50.61	22210691
194	Phosphorylation	KKTAPEKSLVSDKTS CCCCCCCCCCCCCCC	32.13	23312004
197	Phosphorylation	APEKSLVSDKTSISE CCCCCCCCCCCCHHH	38.39	23312004
200	Phosphorylation	KSLVSDKTSISEKVL CCCCCCCCCHHHHHH	35.96	28355574
201	Phosphorylation	SLVSDKTSISEKVLA CCCCCCCCHHHHHHH	29.83	23090842
203	Phosphorylation	VSDKTSISEKVLASE CCCCCCHHHHHHHCC	31.00	23090842
209	Phosphorylation	ISEKVLASEKTSLSE HHHHHHHCCCCCHHH	35.15	29759185
212	Phosphorylation	KVLASEKTSLSEKIA HHHHCCCCCHHHHHH	30.74	29759185
213	Phosphorylation	VLASEKTSLSEKIAV HHHCCCCCHHHHHHH	40.75	29759185
215	Phosphorylation	ASEKTSLSEKIAVSE HCCCCCHHHHHHHHH	36.29	29759185
221	Phosphorylation	LSEKIAVSEKRNSSE HHHHHHHHHCCCCHH	28.51	23312004
236	Phosphorylation	KKSVLEKTSVSEKSL HCHHHHHCCCCHHHC	25.61	-
237	Phosphorylation	KSVLEKTSVSEKSLA CHHHHHCCCCHHHCC	34.41	-
251	Phosphorylation	APGMALGSGRRLVSE CCCCCCCCCCHHHHH	29.94	28857561
257	Phosphorylation	GSGRRLVSEKASIFE CCCCHHHHHHHHHHH	37.66	28857561
259	Acetylation	GRRLVSEKASIFEKA CCHHHHHHHHHHHHH	39.67	70501
259	Methylation	GRRLVSEKASIFEKA CCHHHHHHHHHHHHH	39.67	70501
261	Phosphorylation	RLVSEKASIFEKALA HHHHHHHHHHHHHHH	38.59	28857561
269	Phosphorylation	IFEKALASEKSPTAD HHHHHHHCCCCCCCC	46.54	23927012
272	Phosphorylation	KALASEKSPTADAKP HHHHCCCCCCCCCCC	24.35	28731282
274	Phosphorylation	LASEKSPTADAKPAP HHCCCCCCCCCCCCC	44.23	23927012
285	Phosphorylation	KPAPKRATASEQPLA CCCCCCCCCCCCCCC	34.45	23312004
287	Phosphorylation	APKRATASEQPLAQE CCCCCCCCCCCCCCC	32.20	23312004
298	Phosphorylation	LAQEPPASGGSPATT CCCCCCCCCCCCCCC	49.84	22617229
301	Phosphorylation	EPPASGGSPATTKEQ CCCCCCCCCCCCHHH	18.19	23911959
304	Phosphorylation	ASGGSPATTKEQRGR CCCCCCCCCHHHHCC	41.61	29116813
305	Phosphorylation	SGGSPATTKEQRGRA CCCCCCCCHHHHCCC	34.39	29496963
320	Phosphorylation	LPGKNLPSLAKQGAS CCCCCHHHHHHCCCC	44.09	27470641
347	Phosphorylation	TLQVKIPSKEEEADM EEEEECCCHHHHCCC	57.06	23927012
355	Phosphorylation	KEEEADMSSPTQRTY HHHHCCCCCCCHHHH	33.44	23927012
356	Phosphorylation	EEEADMSSPTQRTYS HHHCCCCCCCHHHHC	25.90	28355574
358	Phosphorylation	EADMSSPTQRTYSSS HCCCCCCCHHHHCHH	32.41	30278072
361	Phosphorylation	MSSPTQRTYSSSLKR CCCCCHHHHCHHCCC	20.24	23090842
362	Phosphorylation	SSPTQRTYSSSLKRS CCCCHHHHCHHCCCC	14.56	23090842
363	Phosphorylation	SPTQRTYSSSLKRSS CCCHHHHCHHCCCCC	16.91	21406692
364	Phosphorylation	PTQRTYSSSLKRSSP CCHHHHCHHCCCCCC	29.31	26657352
365	Phosphorylation	TQRTYSSSLKRSSPR CHHHHCHHCCCCCCC	31.78	25394399
367	Methylation	RTYSSSLKRSSPRTI HHHCHHCCCCCCCEE	52.78	24129315
369	Phosphorylation	YSSSLKRSSPRTISF HCHHCCCCCCCEEEE	43.01	17081983
370	Phosphorylation	SSSLKRSSPRTISFR CHHCCCCCCCEEEEE	23.57	23911959
373	Phosphorylation	LKRSSPRTISFRMKP CCCCCCCEEEEEECC	25.10	27282143
375	Phosphorylation	RSSPRTISFRMKPKK CCCCCEEEEEECCCC	13.24	29496963
385	Phosphorylation	MKPKKENSETTLTRS ECCCCCCCCCCEEEE	37.09	26657352
387	Phosphorylation	PKKENSETTLTRSAS CCCCCCCCCEEEEHH	27.25	25072903
388	Phosphorylation	KKENSETTLTRSASM CCCCCCCCEEEEHHC	23.29	30242111
390	Phosphorylation	ENSETTLTRSASMKL CCCCCCEEEEHHCCC	22.08	27251275
392	Phosphorylation	SETTLTRSASMKLPD CCCCEEEEHHCCCCC	21.33	23927012
394	Phosphorylation	TTLTRSASMKLPDNT CCEEEEHHCCCCCCC	20.07	28355574
401	Phosphorylation	SMKLPDNTVKLGEKL HCCCCCCCEEHHHHH	26.80	23927012
413	Phosphorylation	EKLERYHTAIRRSES HHHHHHHHHHHHCHH	18.16	-
420	Phosphorylation	TAIRRSESVKSRGLP HHHHHCHHHHHCCCC	35.77	28176443
423	Phosphorylation	RRSESVKSRGLPCTE HHCHHHHHCCCCCCE	29.44	25394399
424	Methylation	RSESVKSRGLPCTEL HCHHHHHCCCCCCEE	44.97	24129315
429	Phosphorylation	KSRGLPCTELFVAPV HHCCCCCCEEEEECC	33.51	22617229
440	Phosphorylation	VAPVGVASKRHLFEK EECCCHHHHHHHHHH	28.02	27050516
441	Acetylation	APVGVASKRHLFEKE ECCCHHHHHHHHHHH	33.81	24431011
441	Methylation	APVGVASKRHLFEKE ECCCHHHHHHHHHHH	33.81	24431011
453	Phosphorylation	EKELAGQSRAEPASS HHHHHCCCCCCCCCH	32.32	25056879
459	Phosphorylation	QSRAEPASSRKENLR CCCCCCCCHHHHHHC	41.20	19362540
460	Phosphorylation	SRAEPASSRKENLRL CCCCCCCHHHHHHCH	49.86	19362540
468	Phosphorylation	RKENLRLSGVVTSRL HHHHHCHHHEEEHHH	24.09	26657352
472	Phosphorylation	LRLSGVVTSRLNLWI HCHHHEEEHHHEEEE	13.01	23090842
473	Phosphorylation	RLSGVVTSRLNLWIS CHHHEEEHHHEEEEE	24.14	28857561
480	Phosphorylation	SRLNLWISRTQESGD HHHEEEEECCCCCCC	20.07	23090842
482	Phosphorylation	LNLWISRTQESGDQD HEEEEECCCCCCCCC	29.87	23090842
485	Phosphorylation	WISRTQESGDQDPQE EEECCCCCCCCCHHH	37.54	22617229
497	Phosphorylation	PQEAQKASSATERTQ HHHHHHHHHHHHHHH	27.78	23312004
498	Phosphorylation	QEAQKASSATERTQW HHHHHHHHHHHHHHH	44.03	23911959
500	Phosphorylation	AQKASSATERTQWGQ HHHHHHHHHHHHHCC	28.13	23312004
503	Phosphorylation	ASSATERTQWGQKSD HHHHHHHHHHCCCCC	23.57	28102081
509	Phosphorylation	RTQWGQKSDSSLDAE HHHHCCCCCCCCCCC	34.53	28857561
511	Phosphorylation	QWGQKSDSSLDAEV- HHCCCCCCCCCCCC-	39.63	28857561
512	Phosphorylation	WGQKSDSSLDAEV-- HCCCCCCCCCCCC--	34.95	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, AND MASSSPECTROMETRY.
PubMed: 16083285