KRA33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KRA33_HUMAN
• UniProt AC: Q9BYR6
• Protein Name: Keratin-associated protein 3-3
• Gene Name: KRTAP3-3
• Organism: Homo sapiens (Human).
• Sequence Length: 98
• Protein Description: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins..
• Protein Sequence: MDCCASRGCSVPTGPATTICSSDKSCRCGVCLPSTCPHTVWLLEPTCCDNCPPPCHIPQPCVPTCFLLNSCQPTPGLETLNLTTFTQPCCEPCLPRGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDCCASRGCSVPT --CCCCCCCCCCCCC	18.45	-
10	Phosphorylation	CCASRGCSVPTGPAT CCCCCCCCCCCCCCE	33.68	-
21	Phosphorylation	GPATTICSSDKSCRC CCCEEEECCCCCCCC	37.41	-
22	Phosphorylation	PATTICSSDKSCRCG CCEEEECCCCCCCCC	44.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KRA33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KRA33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KRA33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCE3C_HUMAN	LCE3C	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.