KPBA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPBA_DROME
• UniProt AC: Q9W391
• Protein Name: Probable phosphorylase b kinase regulatory subunit alpha
• Gene Name: CG7766
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1247
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (By similarity)..
• Protein Sequence: MRSRSNSGVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHAWIRDNVYCILAVWGLSMAYKKIADQDEDRAKCYELEQSCVKLMRGLLMAMMNQKDKVEKFKMTQSPYDSLHAKYSSKNGLPVVDDNEWGHLQIDAVSLYLLILAQMTASGLQIVFSLDEVSFIQNLVFYIESAYSIPDYGIWERGDKTNHGEPELNASSIGMAKAALEAMNELDLFGARGGPASVIHVLADEAHKCQAVLQSMLPRESNSKELDSGLLCVIGFPAFAVDDAQLIHNTKDAILSRLQGKYGCKRFLRDGYRTPKEDPSRLYYERWELRMFENIECEWPLFYCYLILFHAFQSDKRAVEEYASRLEKIMVRSEDGILLVPESYAVPQDLVGFEYQKPGSQVREVVGRCPFLWGQSLFILGRLLQEGFLAVGELDPLNRRLGAQKKPDVVVQVVIIAEDNEIRDKLAEHDLHVQTIAEVAPIEVQPARVLSHLYTYLGRNRKLGLSGRKSRDVGILSTSKLYSLKDRIFAFTPQFADLSRFYIASDNELMIDILKGEINFLKSAWDLLGRPLVTLVLKRIHLDQDKIPLAMIQTMRKLKSGYINGTRVMLGSLKDFLNTSAITDLSFLGSTEDGYPDRLHPDVQTYLDEHLLRSFSNRSTMNLRGGQLRPRTLRRRMSCKGAIKKTRSINVDSDNLGMEGPSPLTERRLSSIVPPPWLQANKQSHVSVFATTPEEGPTSSPLSLGNDLIRENIYPVDPHHSRSAIDRRSEFVRQQEMPKILIQRHRAETNFADTEVEELIAMLRETENLEEQGDILQYLVDTQGLDFNTAGLGFKNKSEENATPNANNAGMLEEGRVVTVRDLLKGLYEKACQQKLWGLVRHTAGMLGKRVEDLAKAVTDLLVRQKQVTVGMPPNNEHTITAPLPEVELRQLIHDAYGDDESTAMLTQELMVYLAMFIRTEPQLFHEMLRLRVGLIIQVMAKELSRTLNCDGEAASEHLLNLSPFEMKNLLYHILSGKEFAVSSVARGNLSIVSCKSSRVSKKSQIGLGDPEGEDALIATIDDRQGQWLRRRRLDGALNRVPRDFYSRVWTVLEKCQGLAIEGRVLQQSLTQEMTPGELKFALEVETALNQIPQPEYRQLVVEALMVLTLVTEHNMVPSLGGVIYVEHLVHKANQLFLEDQRKVQGDATLCCAKIKDGKEQQQAASGMLLCGGAAYICQHLYDSAPSGSYGTMTYMSRAVALVLDCVPKHGEMECAIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
677	Phosphorylation	GAIKKTRSINVDSDN CHHCCCCCCCCCCCC	24.60	23607784
721	Phosphorylation	HVSVFATTPEEGPTS CEEEEEECCCCCCCC	25.85	21082442
1012	Phosphorylation	SGKEFAVSSVARGNL HCCCCEEHHHHCCCE	18.70	23607784
1013	Phosphorylation	GKEFAVSSVARGNLS CCCCEEHHHHCCCEE	17.13	28490779
1020	Phosphorylation	SVARGNLSIVSCKSS HHHCCCEEEEEECCC	25.58	28490779
1023	Phosphorylation	RGNLSIVSCKSSRVS CCCEEEEEECCCCCC	17.73	28490779
1030	Phosphorylation	SCKSSRVSKKSQIGL EECCCCCCCCHHCCC	33.00	22817900
1033	Phosphorylation	SSRVSKKSQIGLGDP CCCCCCCHHCCCCCC	30.66	19429919
1244	Farnesylation	PKHGEMECAIS---- CCCCCEEEECC----	3.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPBA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPBA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPBA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPBB_DROME	CG8475	physical	22036573
RM23_DROME	mRpL23	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1030 AND SER-1033, ANDMASS SPECTROMETRY.
PubMed: 18327897