KPBB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPBB_DROME
• UniProt AC: Q9VLS1
• Protein Name: Probable phosphorylase b kinase regulatory subunit beta
• Gene Name: CG8475
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1093
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity)..
• Protein Sequence: MRDVPKSLGLSVTTPGGSSGAPDSGRHNSLEEINLDQFLKTSNYEDTVKQLDIYYGIVKRQLLRYQSPITGLFPVMSTDQVVGSVRDSVYCASAVWSLYQAYRRIDDDRGKSYELGQSTVKCMRGILECWVKQASRVELFKQRQSNQHALHSKFQLHTGEKIYPDEFYNHLQIDCVSLYLLFLVQMITSGLQIIYTHDEVAFVQNLVYYVERAYRTPDFGMWERGSKYNNGTPEIHASSIGMAKSALEAINGCNLFGEKGASWSVVYVDIDAHNRNRSIFETMLPRESSSKGVDASLLLTLSFPAFASHEDRLVEQTKQNVVNRLRCKMGFKRFTRDGFLSKNEDKSRRYYHSGELKEFEGLECEWPLFFIAMIIDGVFKNNNEQIEEFQNDLRRCLRTDVNGDPVVTMYYAPDGDGSYMRAPSQSLFLWGQSFFIIAQLLTAGLLHINELDPIRRYLPSYNRPRRAGRYSAFQGTATDLVVQIVLIAESMRLQAMMATYGIQTQTPHEVEPVQIWSSTELIKVYQHLGVNNKVGLSGRPCRPVGSLGTSKVYRICGMTVLCYPLIFEVSDFYLYRDMALLIDDIKTELQFVGKYWRLSGRPTVCLLIREEHMRDPQFKEMLDLLAMLKKGYCDGMKVRIGRLQNLISSSCIEHLDFMNQSDLTDNENAFSQINHEYIGYQSLTDVPKALTYVEEKISVAHFDTKPTPDIINALRSTDSIYCLCQLWGIILNREGPHFEVNGLNVNTALTQLYHRAGSLRYWRAVRYCSSLLHHIVDSISPFITTVLVNGKELTVGIIGQKETVFDKPMTPAEIQNVMYTSVQPYDVIQAVLQQEVVLYCGRLIATNPSMFRGILKIRIGWVLEAMRIYLQISGQQSIDVDNLSPFQVRILLQKVLTVSEWAVEEKLTTLQRRQLEGCLCRVPKHFYNKIWEILQRTPQGILTQGHHLPATPTLTNMSRGELTFNLLVEETLICIDRPERRQITVELLCIVATILNRNPELHFKQALDLDGILAEAFAMYCKDNNIQHQPKPEHEQTKNEDLKAFYSLPYSETTGYLARAAVNKVLQGGIFSTNEEDVQLDGDRLHDDNCKVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	GSSGAPDSGRHNSLE CCCCCCCCCCCCCHH	36.35	27794539
29	Phosphorylation	PDSGRHNSLEEINLD CCCCCCCCHHHCCHH	30.91	19429919
929	Acetylation	VPKHFYNKIWEILQR CCHHHHHHHHHHHHH	37.50	21791702
1090	Farnesylation	DRLHDDNCKVS---- CCCCCCCCCCC----	6.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPBB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPBB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPBB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RM23_DROME	mRpL23	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.