KLK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK4_HUMAN
• UniProt AC: Q9Y5K2
• Protein Name: Kallikrein-4
• Gene Name: KLK4
• Organism: Homo sapiens (Human).
• Sequence Length: 254
• Subcellular Localization: Secreted.
• Protein Description: Has a major role in enamel formation. [PubMed: 15235027 Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity]
• Protein Sequence: MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Phosphorylation	QMVEASLSVRHPEYN CCEEEEEEECCCCCC	18.01	24719451
169	N-linked_Glycosylation	PTVLQCVNVSVVSEE CCEEEEEEEECCCHH	28.15	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCIP4_HUMAN	KCNIP4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.