KLF9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF9_HUMAN
• UniProt AC: Q13886
• Protein Name: Krueppel-like factor 9
• Gene Name: KLF9
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation. [PubMed: 22711835]
• Protein Sequence: MSAAAYMDFVAAQCLVSISNRAAVPEHGVAPDAERLRLPEREVTKEHGDPGDTWKDYCTLVTIAKSLLDLNKYRPIQTPSVCSDSLESPDEDMGSDSDVTTESGSSPSHSPEERQDPGSAPSPLSLLHPGVAAKGKHASEKRHKCPYSGCGKVYGKSSHLKAHYRVHTGERPFPCTWPDCLKKFSRSDELTRHYRTHTGEKQFRCPLCEKRFMRSDHLTKHARRHTEFHPSMIKRSKKALANAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	VAAQCLVSISNRAAV HHHHHHHHHHHCCCC	13.83	24043423
19	Phosphorylation	AQCLVSISNRAAVPE HHHHHHHHHCCCCCC	16.86	24043423
103	Phosphorylation	DSDVTTESGSSPSHS CCCCCCCCCCCCCCC	41.71	24275569
119	Phosphorylation	EERQDPGSAPSPLSL HHHCCCCCCCCCHHH	42.25	29255136
122	Phosphorylation	QDPGSAPSPLSLLHP CCCCCCCCCHHHCCC	37.88	29255136
125	Phosphorylation	GSAPSPLSLLHPGVA CCCCCCHHHCCCCCC	32.06	29255136
147	Phosphorylation	EKRHKCPYSGCGKVY CCCCCCCCCCCCCEE	27.45	29083192
148	Phosphorylation	KRHKCPYSGCGKVYG CCCCCCCCCCCCEEC	16.85	29083192
154	Phosphorylation	YSGCGKVYGKSSHLK CCCCCCEECCCHHCE	23.48	29083192
156	Ubiquitination	GCGKVYGKSSHLKAH CCCCEECCCHHCEEE	30.97	-
157	Phosphorylation	CGKVYGKSSHLKAHY CCCEECCCHHCEEEE	20.73	29083192
158	Phosphorylation	GKVYGKSSHLKAHYR CCEECCCHHCEEEEE	36.00	29083192
196	Phosphorylation	ELTRHYRTHTGEKQF HHHHHHHCCCCCCCC	19.34	-
198	Phosphorylation	TRHYRTHTGEKQFRC HHHHHCCCCCCCCCC	46.56	-
215	Phosphorylation	CEKRFMRSDHLTKHA CHHHHHCCHHHHHHH	20.00	26074081
219	Phosphorylation	FMRSDHLTKHARRHT HHCCHHHHHHHHHHH	19.84	26074081
220	Ubiquitination	MRSDHLTKHARRHTE HCCHHHHHHHHHHHH	41.44	21906983
226	Phosphorylation	TKHARRHTEFHPSMI HHHHHHHHHCCHHHH	38.24	29759185
238	Sumoylation	SMIKRSKKALANAL- HHHHHHHHHHHHHC-	50.29	-
238	Sumoylation	SMIKRSKKALANAL- HHHHHHHHHHHHHC-	50.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLF9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRGR_HUMAN	PGR	physical	12672823
SIN3A_HUMAN	SIN3A	physical	11438660
SP1_HUMAN	SP1	physical	17717078

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.