KISSR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KISSR_HUMAN
• UniProt AC: Q969F8
• Protein Name: KiSS-1 receptor
• Gene Name: KISS1R
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins..
• Protein Sequence: MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLGEDNAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	N-linked_Glycosylation	TVATSGPNASWGAPA CCCCCCCCCCCCCCC	50.56	UniProtKB CARBOHYD
18	N-linked_Glycosylation	ASWGAPANASGCPGC CCCCCCCCCCCCCCC	33.31	UniProtKB CARBOHYD
28	N-linked_Glycosylation	GCPGCGANASDGPVP CCCCCCCCCCCCCCC	25.84	UniProtKB CARBOHYD
368	Phosphorylation	AELLRLGSHPAPARA HHHHHCCCCCCCHHC	30.78	23917254

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KISSR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KISSR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KISSR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KISS1_HUMAN	KISS1	physical	11457843
PP2AA_HUMAN	PPP2CA	physical	18977201
PTPA_HUMAN	PPP2R4	physical	18977201

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.