KELL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KELL_HUMAN
• UniProt AC: P23276
• Protein Name: Kell blood group glycoprotein
• Gene Name: KEL
• Organism: Homo sapiens (Human).
• Sequence Length: 732
• Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
• Protein Description: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3..
• Protein Sequence: MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEGGDQSEEEPRER -CCCCCCCCCCHHHH	52.28	8669078
15	Phosphorylation	EEEPRERSQAGGMGT CCCHHHHHHCCCCCC	21.45	23025827
94	N-linked_Glycosylation	DHYLASGNTSVAPCT HHHHCCCCCCCCCCC	27.04	UniProtKB CARBOHYD
115	N-linked_Glycosylation	CGRAKETNNSFQELA CCCCHHHCCHHHHHH	43.15	UniProtKB CARBOHYD
186	Phosphorylation	WRISGKWTSLNFNRT CEEECCEECCCHHHH	27.16	29083192
187	Phosphorylation	RISGKWTSLNFNRTL EEECCEECCCHHHHH	21.87	29083192
191	N-linked_Glycosylation	KWTSLNFNRTLRLLM CEECCCHHHHHHHHH	34.65	11336649
201	Phosphorylation	LRLLMSQYGHFPFFR HHHHHHHHCCCHHHH	12.78	-
272	Phosphorylation	PSKVQEHSSLSISIT HHHHCCCCCCHHHHH	32.02	-
303	Phosphorylation	GKLFQMVTIDQLKEM CCEEEEEEHHHHHHH	17.31	26074081
345	N-linked_Glycosylation	HDVEYLKNMSQLVEE CCHHHHHCHHHHHHH	32.51	UniProtKB CARBOHYD
444	Phosphorylation	SAAMKLFTAIRDALI HHHHHHHHHHHHHHH	31.45	21712546
452	Phosphorylation	AIRDALITRLRNLPW HHHHHHHHHHHCCCC	25.22	21712546
502	Phosphorylation	YNDIQLGSSFLQSVL CCCHHHHHHHHHHHH	26.89	22210691
627	N-linked_Glycosylation	LPSRTSFNDSLTFLE CCCCCCCCCCCHHHH	37.42	UniProtKB CARBOHYD
706	Phosphorylation	LRVHGPLSSTPAFAR EEECCCCCCCHHHHH	34.99	29449344
707	Phosphorylation	RVHGPLSSTPAFARY EECCCCCCCHHHHHH	46.20	29449344
708	Phosphorylation	VHGPLSSTPAFARYF ECCCCCCCHHHHHHH	18.43	29449344
714	Phosphorylation	STPAFARYFRCARGA CCHHHHHHHHHHHCC	7.61	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KELL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KELL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
272	Phosphorylation	281 (9)	R ⇒ W	rs8176059	Immature fraction of reticulocytes High light scatter reticulocyte count High light scatter reticulocyte percentage of red cells	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA1A_HUMAN	TUBA1A	physical	21900206

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.