KDM6B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM6B_MOUSE
• UniProt AC: Q5NCY0
• Protein Name: Lysine-specific demethylase 6B
• Gene Name: Kdm6b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1641
• Subcellular Localization: Nucleus.
• Protein Description: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. [PubMed: 17825402 Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex]
• Protein Sequence: MHRAVDPPGARSAREAFALGGLSCAGAWSSCPPHPPPRSSWLPGGRCSASVGQPPLSAPLPPSHGSSSGHPNKPYYAPGTPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESEHDSEEAVCCYHRALRYGGSFAELGPRIGRLQQAQLWNFHAGSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRSAEPPVVQPMPPAALSGPSGEEGLSPGGKRRRGCSSEQAGLPPGLPLPPPPPPPPPPPPPPPPPPPPLPGLAISPPFQLTKPGLWNTLHGDAWGPERKGSAPPERQEQRHSMPHSYPYPAPAYSAHPPSHRLVPNTPLGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPGLPGTSSSSSSSSSSNNTGLRGVEPSPGIPGADHYQNPALEISPHQARLGPSAHSSRKPFLTAPAATPHLSLPPGTPSSPPPPCPRLLRPPPPPAWMKGSACRAAREDGEILGELFFGAEGPPRPPPPPLPHRDGFLGPPNPRFSVGTQDSHNPPIPPTTTSSSSSSNSHSSSPTGPVPFPPPSYLARSIDPLPRPSSPTLSPQDPPLPPLTLALPPAPPSSCHQNTSGSFRRSESPRPRVSFPKTPEVGQGPPPGPVSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQQQEAGVAPPPPLKEPFASLQPPFPSDTAPATTTAAPTTATTTTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPQPPPPPPASPASLLKSLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKPSVSSSSQFSTSGGPWAREHRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRACETLVERVGRSAINPVDTADPVDSGTEPQPPPAQAKEESGGVAVAAAGPGSGKRRQKEHRRHRRACRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDVGGVSKVKTPTAPAPPPAPAPAAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEERESEDEESEEPDSTTGTSPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
215	Phosphorylation	PMPPAALSGPSGEEG CCCCHHHCCCCCCCC	43.88	28285833
218	Phosphorylation	PAALSGPSGEEGLSP CHHHCCCCCCCCCCC	63.46	26643407
224	Phosphorylation	PSGEEGLSPGGKRRR CCCCCCCCCCCCCCC	32.15	26643407
472	Phosphorylation	LPPGTPSSPPPPCPR CCCCCCCCCCCCCCC	42.50	26060331
590	Phosphorylation	IDPLPRPSSPTLSPQ CCCCCCCCCCCCCCC	50.67	26060331
591	Phosphorylation	DPLPRPSSPTLSPQD CCCCCCCCCCCCCCC	25.29	26060331
593	Phosphorylation	LPRPSSPTLSPQDPP CCCCCCCCCCCCCCC	41.64	26060331
595	Phosphorylation	RPSSPTLSPQDPPLP CCCCCCCCCCCCCCC	24.00	26060331
627	Phosphorylation	TSGSFRRSESPRPRV CCCCCCCCCCCCCCC	37.86	23684622
629	Phosphorylation	GSFRRSESPRPRVSF CCCCCCCCCCCCCCC	27.70	23684622
639	Phosphorylation	PRVSFPKTPEVGQGP CCCCCCCCCCCCCCC	25.56	25338131
801	Phosphorylation	PPPPPPASPASLLKS CCCCCCCCHHHHHHH	27.11	28285833
975	Acetylation	AAGPGSGKRRQKEHR ECCCCCCHHHHHHHH	46.21	30986471
1040	Phosphorylation	RPDVGGVSKVKTPTA CCCCCCCCCCCCCCC	34.70	21454597
1094	Phosphorylation	MLKLRSLSEGPPKEL HHHHHHCCCCCCCCC	41.58	27600695
1196	Phosphorylation	ESKRDAFSPVLLQFC CCCCCCCCHHHHHHC	18.80	30635358
1204	Phosphorylation	PVLLQFCTDPRNPIT HHHHHHCCCCCCCHH	50.78	30635358
1296	Phosphorylation	SLQEERESEDEESEE HHHHHHHCCCCCCCC	57.48	21149613
1301	Phosphorylation	RESEDEESEEPDSTT HHCCCCCCCCCCCCC	45.25	21149613
1551	Phosphorylation	HCQVQRESLVRAGKK CCHHCHHHHHHHCCC	34.06	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1044	T	Phosphorylation	Kinase	PKACA	P05132	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM6B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM6B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMCA4_MOUSE	Smarca4	physical	21095589
SMRC1_MOUSE	Smarcc1	physical	21095589
H33_MOUSE	H3f3a	physical	17825402
PHF20_MOUSE	Phf20	physical	23452852
TRI26_MOUSE	Trim26	physical	23452852

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.