KDM5B_MOUSE - dbPTM
KDM5B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KDM5B_MOUSE
UniProt AC Q80Y84
Protein Name Lysine-specific demethylase 5B
Gene Name Kdm5b
Organism Mus musculus (Mouse).
Sequence Length 1544
Subcellular Localization Nucleus .
Protein Description Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2..
Protein Sequence MEPATTLPPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTSDTKDKEYKPHDIPQRQSVQPAETCPPARRAKRMRAEAMNIKIEPEEATEARTHNLRRRMGCTTPKWENEKEMKSTIKQEPTEKKDCELESEKEKPKSRAKKTATAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLVPPLHDVPKGDWRCPKCLAQECNKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKISPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQQSQKLLSEEMPSAAELQELLDVSFEFDVELPQLTEMRIRLEQARWLEEVQQACLDSSSLSLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTVLKDSVQRARDWVQDVDALQAGGRVPVLETLIELVARGRSIPVHLNSLPRLEMLVAEVHAWKECAAKTFLPENSTYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPSGKKRSTKLESLSDLERALMESKETAAAMATLGEARLREMEALQSLRFANEEKLLSPVQDLEMKVCLCQKTPATPMIQCELCRDAFHTSCVAAPSISQSSRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKLVQDQVGSGLLSSRWPASAGQASATDKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGQSCLPLHGLSPEVNELLMEAQLLQVSLPEIQELYQTLLTKPSSVQQADRSSPVRSSSEKNDCLRGKRDAINSPERKLKRRPEREGLPSERWDRVKHMRTPQKKKIKLSHPKDMDSFKLERERSYDLVRNAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTGKDAPSRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
100UbiquitinationLEAQTRVKLNFLDQI
HHHHHHHHHHHHHHH		34.1322790023
200PhosphorylationCLQKPNLTSDTKDKE
HCCCCCCCCCCCCCC		31.0619854140
264PhosphorylationRRRMGCTTPKWENEK
HHHCCCCCCCCCCHH		27.2629514104
278SumoylationKEMKSTIKQEPTEKK
HHHHHHCCCCCCCHH		49.0128289178
628PhosphorylationLHRYCVFSHDEMICK
HHHHHCCCCCHHHHH		15.0524759943
697PhosphorylationRQCIKCKTTCFMSAI
HHHHCCCCHHHHHHH		37.9622807455
705PhosphorylationTCFMSAISCSCKPGL
HHHHHHHHCCCCCCH		10.3322807455
742PhosphorylationRYTLDDLYPMMNALK
EEEHHHHHHHHHHHH		8.9729895711
774AcetylationEAKINKKKSLVSFKA
HHHCCCCCCHHHHHH		51.116567309
832AcetylationRYRSGGGKSQNQLTV
CCCCCCCCCCCCCCH		52.7423806337
832UbiquitinationRYRSGGGKSQNQLTV
CCCCCCCCCCCCCCH		52.7422790023
986PhosphorylationLRARPRHSLSSLATA
HHHCCCCCHHHHHHH		31.0928833060
988PhosphorylationARPRHSLSSLATAVK
HCCCCCHHHHHHHHH		26.7328833060
989PhosphorylationRPRHSLSSLATAVKE
CCCCCHHHHHHHHHH		27.5828833060
992PhosphorylationHSLSSLATAVKEMEE
CCHHHHHHHHHHHHH		36.9628833060
1124PhosphorylationKRSTKLESLSDLERA
CCCHHHHHHHHHHHH		43.5428066266
1126PhosphorylationSTKLESLSDLERALM
CHHHHHHHHHHHHHH		49.8028066266
1136UbiquitinationERALMESKETAAAMA
HHHHHHCHHHHHHHH		45.8622790023
1169PhosphorylationANEEKLLSPVQDLEM
CCHHHCCCCCCCCCE		33.2022006019
1276UbiquitinationLLSSGNLKLVQDQVG
HHHCCCCEEEECCCC		51.08-
1328PhosphorylationNRTSYLHSPFSTGQS
CCCCCCCCCCCCCCC		25.66-
1376PhosphorylationTLLTKPSSVQQADRS
HHHHCCHHHHCCCCC		32.2623375375
1383PhosphorylationSVQQADRSSPVRSSS
HHHCCCCCCCCCCCH		39.2729472430
1384PhosphorylationVQQADRSSPVRSSSE
HHCCCCCCCCCCCHH		28.4526824392
1388PhosphorylationDRSSPVRSSSEKNDC
CCCCCCCCCHHHCCH		38.1523375375
1405PhosphorylationGKRDAINSPERKLKR
CCHHHHCCHHHHHHC		23.2526824392
1456PhosphorylationFKLERERSYDLVRNA
CCCHHHHHHHHHHCC		20.4629895711
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KDM5B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KDM5B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KDM5B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MO4L1_MOUSEMorf4l1physical
21448134
HDAC1_MOUSEHdac1physical
21448134
SIN3A_MOUSESin3aphysical
21448134
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KDM5B_MOUSE

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Related Literatures of Post-Translational Modification

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