KCNN3_HUMAN - dbPTM
KCNN3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCNN3_HUMAN
UniProt AC Q9UGI6
Protein Name Small conductance calcium-activated potassium channel protein 3
Gene Name KCNN3
Organism Homo sapiens (Human).
Sequence Length 736
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin..
Protein Sequence MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
133PhosphorylationHPSSRQGSQLNLNDH
CCCCCCCCCCCCCCC		24.1323312004
145PhosphorylationNDHLLGHSPSSTATS
CCCCCCCCCCCCCCC		25.3623312004
147PhosphorylationHLLGHSPSSTATSGP
CCCCCCCCCCCCCCC		43.2523312004
148PhosphorylationLLGHSPSSTATSGPG
CCCCCCCCCCCCCCC		25.9923312004
149PhosphorylationLGHSPSSTATSGPGG
CCCCCCCCCCCCCCC		37.9923312004
151PhosphorylationHSPSSTATSGPGGGS
CCCCCCCCCCCCCCC		34.0123312004
152PhosphorylationSPSSTATSGPGGGSR
CCCCCCCCCCCCCCC		40.2923312004
159PhosphorylationSGPGGGSRHRQASPL
CCCCCCCCCCCCCCC		32.0824719451
164PhosphorylationGSRHRQASPLVHRRD
CCCCCCCCCCCCCCC		15.4928857561
167PhosphorylationHRQASPLVHRRDSNP
CCCCCCCCCCCCCCC		3.6124719451
171PhosphorylationSPLVHRRDSNPFTEI
CCCCCCCCCCCHHHH		53.36-
172PhosphorylationPLVHRRDSNPFTEIA
CCCCCCCCCCHHHHH		44.5923403867
176PhosphorylationRRDSNPFTEIAMSSC
CCCCCCHHHHHHHHC		27.9523403867
185PhosphorylationIAMSSCKYSGGVMKP
HHHHHCCCCCCCCCC		19.5129083192
186PhosphorylationAMSSCKYSGGVMKPL
HHHHCCCCCCCCCCH		17.9924850871
194PhosphorylationGGVMKPLSRLSASRR
CCCCCCHHHHCHHHC		39.4429083192
197PhosphorylationMKPLSRLSASRRNLI
CCCHHHHCHHHCCCE		24.0826425664
199PhosphorylationPLSRLSASRRNLIEA
CHHHHCHHHCCCEEC		28.5326425664
228PhosphorylationPPEIVISSREDNHAH
CCEEEEECCCCCCHH		28.6824719451
273PhosphorylationRKNQNIGYKLGHRRA
CCCCCCCHHHHHHHH		10.1518083107
289PhosphorylationFEKRKRLSDYALIFG
HHHHHHHHHHHHHHH		32.3826074081
291PhosphorylationKRKRLSDYALIFGMF
HHHHHHHHHHHHHHH		10.4226074081
314PhosphorylationTELSWGLYSKDSMFS
CCCCCCCCCHHHHHH		15.1025954137
315PhosphorylationELSWGLYSKDSMFSL
CCCCCCCCHHHHHHH		34.7225954137
318PhosphorylationWGLYSKDSMFSLALK
CCCCCHHHHHHHHHH		26.0125954137
321PhosphorylationYSKDSMFSLALKCLI
CCHHHHHHHHHHHHH		12.2325954137
413PhosphorylationADVDIILSIPMFLRL
CCHHHHHHHHHHHHH		17.78-
442UbiquitinationTDASSRSIGALNKIN
CCCCCCCCCHHHHCC		3.48-
447UbiquitinationRSIGALNKINFNTRF
CCCCHHHHCCCCHHH		39.62-
448UbiquitinationSIGALNKINFNTRFV
CCCHHHHCCCCHHHH		7.4721906983
550UbiquitinationVVAVVARKLELTKAE
HHHHHHHHHCCHHHH		36.25-
555UbiquitinationARKLELTKAEKHVHN
HHHHCCHHHHHHHHH		68.142097226
574UbiquitinationTQLTKRIKNAAANVL
HHHHHHHHHHHHHHH		44.56-
615SumoylationKFLQAIHQLRSVKME
HHHHHHHHHHHCHHH		32.24-
618PhosphorylationQAIHQLRSVKMEQRK
HHHHHHHHCHHHHHH		34.38-
620SumoylationIHQLRSVKMEQRKLS
HHHHHHCHHHHHHHH		37.66-
625UbiquitinationSVKMEQRKLSDQANT
HCHHHHHHHHHHHHH		52.62-
659UbiquitinationDRSEDLEKQIGSLES
HCCHHHHHHHCCHHH		55.29-
663PhosphorylationDLEKQIGSLESKLEH
HHHHHHCCHHHHHHH		30.5022210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCNN3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCNN3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCNN3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
DYN2_HUMANDNM2physical
22952906
RAB5A_HUMANRAB5Aphysical
22952906
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01110Miconazole
DB00721Procaine
Regulatory Network of KCNN3_HUMAN

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Related Literatures of Post-Translational Modification

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