KCNG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNG4_HUMAN
• UniProt AC: Q8TDN1
• Protein Name: Potassium voltage-gated channel subfamily G member 4
• Gene Name: KCNG4
• Organism: Homo sapiens (Human).
• Sequence Length: 519
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed:190
• Protein Description: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. [PubMed: 19074135]
• Protein Sequence: MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	KVGALDASPVDLKKE CCCCCCCCCCCCCCE	25.73	28555341
70	Phosphorylation	INVGGRRYLLPWSTL EEECCEEEEECHHHC	15.95	24719451
76	Phosphorylation	RYLLPWSTLDRFPLS EEEECHHHCCCCCHH	28.89	24719451
83	Phosphorylation	TLDRFPLSRLSKLRL HCCCCCHHHHHHHHH	31.26	24719451
354	Phosphorylation	VMRLARHSLGLQTLG HHHHHHHHHCHHHHC	20.69	-
403	Phosphorylation	SGRVLEFTSIPASYW CCCEEEEEECCHHHH	19.17	27174698
404	Phosphorylation	GRVLEFTSIPASYWW CCEEEEEECCHHHHH	31.71	27174698
408	Phosphorylation	EFTSIPASYWWAIIS EEEECCHHHHHHHHH	18.87	27174698
409	Phosphorylation	FTSIPASYWWAIISM EEECCHHHHHHHHHC	13.69	27174698
415	Phosphorylation	SYWWAIISMTTVGYG HHHHHHHHCEECCCC	12.17	27174698
417	Phosphorylation	WWAIISMTTVGYGDM HHHHHHCEECCCCCC	16.13	27174698
418	Phosphorylation	WAIISMTTVGYGDMV HHHHHCEECCCCCCC	11.86	27174698
421	Phosphorylation	ISMTTVGYGDMVPRS HHCEECCCCCCCCCC	12.96	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNG4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNG4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNB2_HUMAN	KCNB2	physical	19074135
KCNB1_HUMAN	KCNB1	physical	19074135
CYTS_HUMAN	CST4	physical	26186194
CYTN_HUMAN	CST1	physical	26186194
CYTT_HUMAN	CST2	physical	26186194
KCNB1_HUMAN	KCNB1	physical	26242757
CYTT_HUMAN	CST2	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
CYTN_HUMAN	CST1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.