dbPTM

KCNA1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCNA1_RAT
UniProt AC	P10499
Protein Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	Kcna1
Organism	Rattus norvegicus (Rat).
Sequence Length	495
Subcellular Localization	Cell membrane Multi-pass membrane protein . Membrane . Cell projection, axon . Cytoplasmic vesicle . Perikaryon . Endoplasmic reticulum . Cell projection, dendrite . Cell junction . Cell junction, synapse . Cell junction, synapse, presynaptic cell membr
Protein Description	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. [PubMed: 12177193]
Protein Sequence	MTVMSGENADEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTATDQNCVNKSKLLTDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	PGHPQDGSYPRQADH CCCCCCCCCCCCCCC	40.01	22673903
67	Ubiquitination	NTLLGNPKKRMRYFD CCCCCCHHHCCCCCC	57.94	-
88	Phosphorylation	FFDRNRPSFDAILYY CCCCCCCCCCEEEEE	32.30	-
207	N-linked_Glycosylation	GTIHRIDNTTVIYTS CEEEEECCCEEEEEC	34.97	-
243	S-palmitoylation	LVVRFFACPSKTDFF HHHHHHCCCCCCHHH	3.10	-
322	Phosphorylation	LGQTLKASMRELGLL HHHHHHHHHHHHHHH	19.45	-
431	Phosphorylation	QAQLLHVSSPNLASD HHHEEECCCCCCCCC	29.36	22673903
432	Phosphorylation	AQLLHVSSPNLASDS HHEEECCCCCCCCCC	19.40	22673903
437	Phosphorylation	VSSPNLASDSDLSRR CCCCCCCCCCCCCCC	40.59	22673903
439	Phosphorylation	SPNLASDSDLSRRSS CCCCCCCCCCCCCCC	37.65	22673903
446	Phosphorylation	SDLSRRSSSTISKSE CCCCCCCCCCCCHHH	29.68	8038169

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
322	S	Phosphorylation	Kinase	PKA	-	Uniprot
446	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
243	C	Palmitoylation	-
Palmitoylated on Cys-243; which may be required for membrane targeting.
446	S	Phosphorylation	8038169
Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCNA1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KCNA1_RAT	Kcna1	physical	19074135

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCNA1_RAT

Related Literatures of Post-Translational Modification