KCAB2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCAB2_RAT
• UniProt AC: P62483
• Protein Name: Voltage-gated potassium channel subunit beta-2
• Gene Name: Kcnab2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 367
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, axon . Cell junction, synapse, synaptosome . Cytoplasm, cytoskeleton . Recruited to the cytoplas
• Protein Description: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. [PubMed: 9763623]
• Protein Sequence: MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPYSKKDYRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MYPESTTGSPAR ---CCCCCCCCCCCE	27.11	28432305
6	Phosphorylation	--MYPESTTGSPARL --CCCCCCCCCCCEE	33.25	25532521
7	Phosphorylation	-MYPESTTGSPARLS -CCCCCCCCCCCEEE	44.96	27097102
9	Phosphorylation	YPESTTGSPARLSLR CCCCCCCCCCEEEEE	17.19	27097102
14	Phosphorylation	TGSPARLSLRQTGSP CCCCCEEEEECCCCC	18.89	25403869
18	Phosphorylation	ARLSLRQTGSPGMIY CEEEEECCCCCCCEE	32.94	28432305
20	Phosphorylation	LSLRQTGSPGMIYST EEEECCCCCCCEEEC	22.97	25403869
25	Phosphorylation	TGSPGMIYSTRYGSP CCCCCCEEECCCCCH	8.63	-
26	Phosphorylation	GSPGMIYSTRYGSPK CCCCCEEECCCCCHH	8.76	28432305
27	Phosphorylation	SPGMIYSTRYGSPKR CCCCEEECCCCCHHH	15.78	-
28	Asymmetric dimethylarginine	PGMIYSTRYGSPKRQ CCCEEECCCCCHHHH	28.07	-
28	Methylation	PGMIYSTRYGSPKRQ CCCEEECCCCCHHHH	28.07	-
31	Phosphorylation	IYSTRYGSPKRQLQF EEECCCCCHHHHHHH	20.50	-
44	Ubiquitination	QFYRNLGKSGLRVSC HHHHHHCCCCCEEEE	44.51	-
104	Ubiquitination	VVLGNIIKKKGWRRS EEECHHHHHCCCCCC	44.64	-
111	Phosphorylation	KKKGWRRSSLVITTK HHCCCCCCCEEEEEE	21.32	28432305
112	Phosphorylation	KKGWRRSSLVITTKI HCCCCCCCEEEEEEE	25.50	25532521
124	Acetylation	TKIFWGGKAETERGL EEEECCCCHHCCCCC	38.83	22902405
124	Ubiquitination	TKIFWGGKAETERGL EEEECCCCHHCCCCC	38.83	-
141	Ubiquitination	KHIIEGLKASLERLQ HHHHHHHHHHHHHHC	46.95	-
268	Ubiquitination	PYSRASLKGYQWLKD CCCHHHHCCHHHHHH	53.75	-
268	Acetylation	PYSRASLKGYQWLKD CCCHHHHCCHHHHHH	53.75	22902405
274	Acetylation	LKGYQWLKDKILSEE HCCHHHHHHHHCCHH	54.75	22902405
276	Ubiquitination	GYQWLKDKILSEEGR CHHHHHHHHCCHHHH	43.91	-
276	Acetylation	GYQWLKDKILSEEGR CHHHHHHHHCCHHHH	43.91	22902405
290	Ubiquitination	RRQQAKLKELQAIAE HHHHHHHHHHHHHHH	56.52	-
290	Acetylation	RRQQAKLKELQAIAE HHHHHHHHHHHHHHH	56.52	22902405
358	Ubiquitination	IDSILGNKPYSKKDY HHHHHCCCCCCCCCC	43.46	-
358	Acetylation	IDSILGNKPYSKKDY HHHHHCCCCCCCCCC	43.46	22902405
360	Phosphorylation	SILGNKPYSKKDYRS HHHCCCCCCCCCCCC	34.43	-
362	Ubiquitination	LGNKPYSKKDYRS-- HCCCCCCCCCCCC--	43.77	-
362	Acetylation	LGNKPYSKKDYRS-- HCCCCCCCCCCCC--	43.77	22902405
363	Ubiquitination	GNKPYSKKDYRS--- CCCCCCCCCCCC---	54.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
9	S	Phosphorylation	Kinase	CDK2	P24941	PSP
9	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
31	S	Phosphorylation	Kinase	CDK2	P24941	PSP
31	S	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCAB2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCAB2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S40A1_RAT	Slc40a1	physical	10477520
KPCZ_RAT	Prkcz	physical	10477520
KCNA2_RAT	Kcna2	physical	10624965

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.