KCNA2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNA2_RAT
• UniProt AC: P63142
• Protein Name: Potassium voltage-gated channel subfamily A member 2
• Gene Name: Kcna2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 499
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Membrane . Cell projection, axon . Cell junction, synapse . Cell junction, synapse, synaptosome . Cell junction, synapse, presynaptic cell membrane . Cell projection, dendrite . Endoplasmic reticulum membrane
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. [PubMed: 12151401]
• Protein Sequence: MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Ubiquitination	LRFETQLKTLAQFPE CCHHHHHHHHHHCCH	31.51	-
49	Acetylation	LRFETQLKTLAQFPE CCHHHHHHHHHHCCH	31.51	22902405
63	Ubiquitination	ETLLGDPKKRMRYFD HHHHCCHHHCCCCCC	58.72	-
64	Ubiquitination	TLLGDPKKRMRYFDP HHHCCHHHCCCCCCC	57.74	-
84	Phosphorylation	FFDRNRPSFDAILYY CCCCCCCCCCEEEEE	32.30	-
207	N-linked_Glycosylation	VTFHTYSNSTIGYQQ EEEEEECCCCEEEEC	32.53	16770729
244	S-palmitoylation	FLVRFFACPSKAGFF HHHHHHCCCCCCCCC	3.10	-
429	Phosphorylation	EGEEQAQYLQVTSCP CCHHHHHEEEEECCC	11.34	-
433	Phosphorylation	QAQYLQVTSCPKIPS HHHEEEEECCCCCCC	16.20	28551015
434	Phosphorylation	AQYLQVTSCPKIPSS HHEEEEECCCCCCCC	29.57	30240740
440	Phosphorylation	TSCPKIPSSPDLKKS ECCCCCCCCCCHHCC	58.96	30411139
441	Phosphorylation	SCPKIPSSPDLKKSR CCCCCCCCCCHHCCC	19.65	30411139
447	Phosphorylation	SSPDLKKSRSASTIS CCCCHHCCCCCCCCC	29.85	22673903
449	Phosphorylation	PDLKKSRSASTISKS CCHHCCCCCCCCCHH	33.39	18003609
458	Phosphorylation	STISKSDYMEIQEGV CCCCHHHHHHHHHHC	12.07	21602278
468	Phosphorylation	IQEGVNNSNEDFREE HHHHCCCCCHHHHHH	36.07	18003609
489	Phosphorylation	CTLANTNYVNITKML CEECCCCCEEHHEEE	7.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNA2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNA2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNA2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.