KC1A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KC1A_RAT
• UniProt AC: P97633
• Protein Name: Casein kinase I isoform alpha
• Gene Name: Csnk1a1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 325
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the centrosome in interphase cells, and to kinetochore
• Protein Description: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity)..
• Protein Sequence: MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSSGSKA ------CCCCCCCCE	20.37	-
3	Phosphorylation	-----MASSSGSKAE -----CCCCCCCCEE	24.60	25575281
4	Phosphorylation	----MASSSGSKAEF ----CCCCCCCCEEE	29.22	25575281
5	Phosphorylation	---MASSSGSKAEFI ---CCCCCCCCEEEE	44.59	25575281
7	Phosphorylation	-MASSSGSKAEFIVG -CCCCCCCCEEEEEC	30.55	25575281
8	Acetylation	MASSSGSKAEFIVGG CCCCCCCCEEEEECC	56.30	22902405
8	Ubiquitination	MASSSGSKAEFIVGG CCCCCCCCEEEEECC	56.30	-
65	Acetylation	LYESKLYKILQGGVG HHHHHHHHHHHCCCC	47.58	22902405
156 (in isoform 2)	Phosphorylation	-	3.02	28432305
311	Phosphorylation	KAAQQAASSSGQGQQ HHHHHHHHCCCCCCC	28.22	27097102
312	Phosphorylation	AAQQAASSSGQGQQA HHHHHHHCCCCCCCC	33.49	27097102
313	Phosphorylation	AQQAASSSGQGQQAQ HHHHHHCCCCCCCCC	32.42	27097102
321	Phosphorylation	GQGQQAQTPTGF--- CCCCCCCCCCCC---	26.32	27097102
323	Phosphorylation	GQQAQTPTGF----- CCCCCCCCCC-----	55.39	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KC1A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KC1A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KC1A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESC_DROME	esc	physical	15896722

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.