IWS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IWS1_SCHPO
• UniProt AC: O42964
• Protein Name: Transcription factor iws1
• Gene Name: iws1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 428
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity)..
• Protein Sequence: MSEEEKAELENMQVESEAKTSENDQTIDTKVDVADVTTHVDEDLDNKEEALDFSEDELSDLDENQFENFDESKIGREAEEPTIYNLPTFKKKQEPNTIEENLEVPRKVRKEQKPRRRRGKRSSTVDALNDELNELGENEEEVLTEQKQLDPTLAAKKELDLQMDAVLKPTRTKKRSNEDNLEQMADDEVLRLREQMRLAALRDAELNSEQLPATEKLKMLPLVDAVLRKTHLYDTILDNNVLDSVRMWLEPLPDRSLPALNIQRSLMDILTKLPIQTEHLRESKIGRIVLFYTISKKPEPFIKRIADNLVSEWSRPIIKRSANYRDRAVGVASFNPEVFQTRRRRDLAAAESNDDAQASRTGRTVIPRSIDSRYQVAPRVRLNPTAMTIAGRMKPADTEQVRKLKAKMKAIRSKSSKKSGVSIEGRGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	QVESEAKTSENDQTI CCCCCCCCCCCCCCC	48.60	21712547
21	Phosphorylation	VESEAKTSENDQTID CCCCCCCCCCCCCCC	33.42	24763107
29	Phosphorylation	ENDQTIDTKVDVADV CCCCCCCEECCHHHH	29.17	21712547
37	Phosphorylation	KVDVADVTTHVDEDL ECCHHHHHCCCCCCC	16.25	24763107
38	Phosphorylation	VDVADVTTHVDEDLD CCHHHHHCCCCCCCC	21.54	21712547
54	Phosphorylation	KEEALDFSEDELSDL HHHHHCCCHHHHHHC	43.75	24763107
59	Phosphorylation	DFSEDELSDLDENQF CCCHHHHHHCCCHHH	33.80	24763107
122	Phosphorylation	RRRRGKRSSTVDALN CCCCCCCCHHHHHHH	33.57	24763107
123	Phosphorylation	RRRGKRSSTVDALND CCCCCCCHHHHHHHH	36.16	21712547
124	Phosphorylation	RRGKRSSTVDALNDE CCCCCCHHHHHHHHH	24.53	29996109
352	Phosphorylation	RDLAAAESNDDAQAS HHHHHHHCCHHHHHH	40.61	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IWS1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IWS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IWS1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SECU_SCHPO	cut2	genetic	15507118
CUT1_SCHPO	cut1	genetic	15507118

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.