ITAL_HUMAN - dbPTM
ITAL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITAL_HUMAN
UniProt AC P20701
Protein Name Integrin alpha-L
Gene Name ITGAL
Organism Homo sapiens (Human).
Sequence Length 1170
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R. [PubMed: 11812992]
Protein Sequence MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MKDSCITVMAM
----CHHHHHHHHHH		20.6422210691
7Phosphorylation-MKDSCITVMAMALL
-CHHHHHHHHHHHHH		14.4622210691
15PhosphorylationVMAMALLSGFFFFAP
HHHHHHHHCCCEECC		34.1122210691
24PhosphorylationFFFFAPASSYNLDVR
CCEECCCHHCCCCCC		32.0922210691
25PhosphorylationFFFAPASSYNLDVRG
CEECCCHHCCCCCCC		21.8322210691
26PhosphorylationFFAPASSYNLDVRGA
EECCCHHCCCCCCCC		19.7622210691
35PhosphorylationLDVRGARSFSPPRAG
CCCCCCCCCCCCCCC		29.5527174698
37PhosphorylationVRGARSFSPPRAGRH
CCCCCCCCCCCCCCC		34.9323401153
65N-linked_GlycosylationVGAPGEGNSTGSLYQ
EECCCCCCCCCCEEE		31.90UniProtKB CARBOHYD
69PhosphorylationGEGNSTGSLYQCQSG
CCCCCCCCEEECCCC		24.8025332170
71PhosphorylationGNSTGSLYQCQSGTG
CCCCCCEEECCCCCC		14.6725332170
89N-linked_GlycosylationPVTLRGSNYTSKYLG
EEEECCCCCCCCCCC		47.10UniProtKB CARBOHYD
130 (in isoform 3)Ubiquitination-17.58-
180UbiquitinationQKILDFMKDVMKKLS
HHHHHHHHHHHHHHC		47.35-
187PhosphorylationKDVMKKLSNTSYQFA
HHHHHHHCCCCCEEE		47.1127732954
188N-linked_GlycosylationDVMKKLSNTSYQFAA
HHHHHHCCCCCEEEE		43.4019349973
188N-linked_GlycosylationDVMKKLSNTSYQFAA
HHHHHHCCCCCEEEE		43.4019349973
189PhosphorylationVMKKLSNTSYQFAAV
HHHHHCCCCCEEEEE		25.9927732954
190PhosphorylationMKKLSNTSYQFAAVQ
HHHHCCCCCEEEEEE		22.6127732954
191PhosphorylationKKLSNTSYQFAAVQF
HHHCCCCCEEEEEEE		12.9527732954
205UbiquitinationFSTSYKTEFDFSDYV
EECCCCCCCCHHHHH		38.7821890473
213UbiquitinationFDFSDYVKRKDPDAL
CCHHHHHHCCCHHHH		47.72-
215UbiquitinationFSDYVKRKDPDALLK
HHHHHHCCCHHHHHH		68.82-
218 (in isoform 3)Ubiquitination-61.04-
222UbiquitinationKDPDALLKHVKHMLL
CCHHHHHHHHHHHHH		47.40-
229 (in isoform 3)Ubiquitination-4.27-
238UbiquitinationTNTFGAINYVATEVF
HCHHHHHHHHHHHHH		25.3721890473
246 (in isoform 3)Ubiquitination-41.47-
246UbiquitinationYVATEVFREELGARP
HHHHHHHHHHHCCCC		41.4721890473
277UbiquitinationSGNIDAAKDIIRYII
CCCHHHHHHHHHHHH		51.70-
288 (in isoform 3)Ubiquitination-39.05-
288UbiquitinationRYIIGIGKHFQTKES
HHHHHCCCCCCCHHH		39.05-
288 (in isoform 1)Ubiquitination-39.0521890473
288 (in isoform 2)Ubiquitination-39.0521890473
293UbiquitinationIGKHFQTKESQETLH
CCCCCCCHHHHHHHH		44.58-
295PhosphorylationKHFQTKESQETLHKF
CCCCCHHHHHHHHHH		34.5724275569
301UbiquitinationESQETLHKFASKPAS
HHHHHHHHHCCCCHH		45.82-
304PhosphorylationETLHKFASKPASEFV
HHHHHHCCCCHHHHH		42.1624275569
305UbiquitinationTLHKFASKPASEFVK
HHHHHCCCCHHHHHH		40.97-
308PhosphorylationKFASKPASEFVKILD
HHCCCCHHHHHHHHH		39.8423401153
312UbiquitinationKPASEFVKILDTFEK
CCHHHHHHHHHHHHH		42.76-
319UbiquitinationKILDTFEKLKDLFTE
HHHHHHHHHHHHHHH		57.56-
321 (in isoform 1)Ubiquitination-64.5521890473
321 (in isoform 2)Ubiquitination-64.5521890473
321UbiquitinationLDTFEKLKDLFTELQ
HHHHHHHHHHHHHHH		64.5521890473
329 (in isoform 1)Ubiquitination-54.4821890473
329 (in isoform 2)Ubiquitination-54.4821890473
329UbiquitinationDLFTELQKKIYVIEG
HHHHHHHHCEEEEEC		54.48-
332PhosphorylationTELQKKIYVIEGTSK
HHHHHCEEEEECCCH		12.31-
333 (in isoform 3)Ubiquitination-3.51-
333UbiquitinationELQKKIYVIEGTSKQ
HHHHCEEEEECCCHH		3.5121890473
338PhosphorylationIYVIEGTSKQDLTSF
EEEEECCCHHHHHHH		38.89-
355PhosphorylationELSSSGISADLSRGH
EECCCCCCCCCCCCC		21.18-
371UbiquitinationVVGAVGAKDWAGGFL
EEECCCCCCCCCCEE		48.12-
406PhosphorylationVRAGYLGYTVTWLPS
HCCCCCCEEEEECCC		8.7423403867
416UbiquitinationTWLPSRQKTSLLASG
EECCCCCHHHHHCCC		38.682189047
416 (in isoform 2)Ubiquitination-38.6821890473
416 (in isoform 1)Ubiquitination-38.6821890473
417PhosphorylationWLPSRQKTSLLASGA
ECCCCCHHHHHCCCC		19.1029759185
422PhosphorylationQKTSLLASGAPRYQH
CHHHHHCCCCCCCEE		35.1429759185
612PhosphorylationSQMIVLSSRPVVDMV
EEEEEEECCCEEEEE		36.1224719451
649N-linked_GlycosylationNKMKEGVNITICFQI
CCCCCCEEEEEEEEH		36.22UniProtKB CARBOHYD
664 (in isoform 3)Ubiquitination-30.74-
670N-linked_GlycosylationFQGRLVANLTYTLQL
HCCEEEEEEEEEEEE		25.9919349973
670N-linked_GlycosylationFQGRLVANLTYTLQL
HCCEEEEEEEEEEEE		25.99UniProtKB CARBOHYD
691 (in isoform 3)Ubiquitination-28.19-
692 (in isoform 3)Ubiquitination-26.48-
726N-linked_GlycosylationQDLISPINVSLNFSL
HHHCCCCEEEEEEEC		22.25UniProtKB CARBOHYD
730N-linked_GlycosylationSPINVSLNFSLWEEE
CCCEEEEEEECEECC		19.56UniProtKB CARBOHYD
747 (in isoform 3)Ubiquitination-28.72-
752 (in isoform 3)Ubiquitination-38.28-
769UbiquitinationTWEIPFEKNCGEDKK
CEECCCCCCCCCCCC		58.90-
769AcetylationTWEIPFEKNCGEDKK
CEECCCCCCCCCCCC		58.907676349
775UbiquitinationEKNCGEDKKCEANLR
CCCCCCCCCEEEEEE		55.83-
776AcetylationKNCGEDKKCEANLRV
CCCCCCCCEEEEEEE		50.027676361
776UbiquitinationKNCGEDKKCEANLRV
CCCCCCCCEEEEEEE		50.02-
786PhosphorylationANLRVSFSPARSRAL
EEEEEEECHHHHHHH		15.3323403867
831UbiquitinationPPGLSFRKVEMLKPH
CCCCCEEEEEECCCC		40.30-
836UbiquitinationFRKVEMLKPHSQIPV
EEEEEECCCCCCCCC		39.10-
839PhosphorylationVEMLKPHSQIPVSCE
EEECCCCCCCCCCHH		38.03-
862N-linked_GlycosylationLSRALSCNVSSPIFK
HHHHHHCCCCCCHHH		33.07UniProtKB CARBOHYD
866 (in isoform 3)Ubiquitination-28.64-
885N-linked_GlycosylationMMFNTLVNSSWGDSV
HHHHHHHCCCCCCCE		33.18UniProtKB CARBOHYD
897N-linked_GlycosylationDSVELHANVTCNNED
CCEEEEEEEEECCCC		20.91UniProtKB CARBOHYD
945UbiquitinationSFTPKGPKIHQVKHM
EEECCCCCEEEEEEE		62.58-
950UbiquitinationGPKIHQVKHMYQVRI
CCCEEEEEEEEEEEE		18.98-
1036PhosphorylationILVQVIGTLELVGEI
HHHHHHHHHEEECEE		13.1122210691
1050PhosphorylationIEASSMFSLCSSLSI
EEHHHHHHHHHHEEE		21.5922210691
1054PhosphorylationSMFSLCSSLSISFNS
HHHHHHHHEEEEECC		25.7422210691
1060N-linked_GlycosylationSSLSISFNSSKHFHL
HHEEEEECCCCCEEE		38.29UniProtKB CARBOHYD
1071N-linked_GlycosylationHFHLYGSNASLAQVV
CEEEECCCCCHHHHH		29.23UniProtKB CARBOHYD
1140PhosphorylationNGIPAEDSEQLASGQ
CCCCCCCHHHHHCCC		20.8123401153
1145PhosphorylationEDSEQLASGQEAGDP
CCHHHHHCCCCCCCC		49.9930108239
1156AcetylationAGDPGCLKPLHEKDS
CCCCCCCCCCCCCCC		50.0026822725
1163PhosphorylationKPLHEKDSESGGGKD
CCCCCCCCCCCCCCC		44.7430108239
1165PhosphorylationLHEKDSESGGGKD--
CCCCCCCCCCCCC--		46.8430108239
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITAL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITAL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITAL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ESM1_HUMANESM1physical
11544294
ICAM1_HUMANICAM1physical
12526797
SHRPN_HUMANSHARPINphysical
24210817
SHRPN_HUMANSHARPINphysical
26600301
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D03959 Efalizumab (USAN/INN); Raptiva (TN)
D04045 Erlizumab (USAN/INN)
D08993 Rovelizumab (USAN/INN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITAL_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-188, AND MASSSPECTROMETRY.

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