ITAE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITAE_HUMAN
• UniProt AC: P38570
• Protein Name: Integrin alpha-E
• Gene Name: ITGAE
• Organism: Homo sapiens (Human).
• Sequence Length: 1179
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers..
• Protein Sequence: MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTNQTWLLVTSPRTKRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQVLVRRPHSLSSELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGEDDVNTARQRRALEKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMMRNFYEKCFECNFALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGSVTKTASAMQHVLDSIFTSSHGSRRKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAAAAADAEAAQYSYLGYAVAVLHKTCSLSYIAGAPRYKHHGAVFELQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHGEEGRVYVYRLSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDGLSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGLADITVGTLGQAVVFRSRPVVRLKVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCFSNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVSQQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVLKRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQFRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVAVKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKDVTELQILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLIVILVILFKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	N-linked_Glycosylation	LHQDPSTNQTWLLVT HCCCCCCCCEEEEEE	41.44	UniProtKB CARBOHYD
271	N-linked_Glycosylation	ASLARVQNITQVGSV HHHHHHCCCEEECCH	36.10	UniProtKB CARBOHYD
279	Phosphorylation	ITQVGSVTKTASAMQ CEEECCHHHHHHHHH	25.11	19845377
321	N-linked_Glycosylation	GIFEDPLNLTTVINS CCCCCCCCCEEEECC	40.50	UniProtKB CARBOHYD
350	Phosphorylation	EEFKSARTARELNLI HHHHHHHHHHHHCCE	29.77	24719451
359	Phosphorylation	RELNLIASDPDETHA HHHCCEECCCCCCCC	42.56	24719451
364	Phosphorylation	IASDPDETHAFKVTN EECCCCCCCCCHHHC	26.36	24719451
372	Phosphorylation	HAFKVTNYMALDGLL CCCHHHCHHHHHHHH	3.71	-
380	Phosphorylation	MALDGLLSKLRYNII HHHHHHHHHHHHEEE	34.39	24719451
384	Phosphorylation	GLLSKLRYNIISMEG HHHHHHHHEEEECCC	22.58	22210691
388	Phosphorylation	KLRYNIISMEGTVGD HHHHEEEECCCCHHH	13.64	22210691
392	Phosphorylation	NIISMEGTVGDALHY EEEECCCCHHHHHHH	14.17	22210691
407	Phosphorylation	QLAQIGFSAQILDER HHHHHCCCEEECCHH	17.66	22210691
444	N-linked_Glycosylation	SRRGRFLNQTAAAAA CCCCCCCCHHHHHHC	34.15	UniProtKB CARBOHYD
549	Phosphorylation	HGEEGRVYVYRLSEQ ECCCCEEEEEEEECC	7.15	22817900
551	Phosphorylation	EEGRVYVYRLSEQDG CCCEEEEEEEECCCC	6.53	22817900
561	Phosphorylation	SEQDGSFSLARILSG ECCCCCEEHHHHHCC	23.87	22964224
726	N-linked_Glycosylation	GLREALLNFTLDVDV CHHHHHHCCEEECCC	28.80	UniProtKB CARBOHYD
782	N-linked_Glycosylation	CEEDCFSNASVKVSY CCCCCCCCCEEEEEE	18.91	UniProtKB CARBOHYD
809	Phosphorylation	QPILDRYTEPFAIFQ CCCHHHCCCCEEEEE	37.77	28258704
853	Phosphorylation	VGLTKELTLNINLTN EECCEEEEEEEECCC	20.89	22210691
857	N-linked_Glycosylation	KELTLNINLTNSGED EEEEEEEECCCCCCC	39.48	UniProtKB CARBOHYD
859	Phosphorylation	LTLNINLTNSGEDSY EEEEEECCCCCCCCC	23.89	22210691
866	Phosphorylation	TNSGEDSYMTSMALN CCCCCCCCEEHHHHC	19.41	22210691
885	Acetylation	LQLKRMQKPPSPNIQ CCCCCCCCCCCCCCC	49.94	19809449
934	N-linked_Glycosylation	LEENAFPNRTADITV ECCCCCCCCEEEEEE	47.70	UniProtKB CARBOHYD
954	N-linked_Glycosylation	NERRSLANETHTLQF HHHHHHCCCCEEEEE	61.05	UniProtKB CARBOHYD
958	Phosphorylation	SLANETHTLQFRHGF HHCCCCEEEEECCCE	29.67	24850871
980	Ubiquitination	SIMYVNTGQGLSHHK EEEEEECCCCCHHCC	17.85	22505724
1006	Ubiquitination	FGAEYQLQICVPTKL CCCEEEEEEECCCCC	16.12	22505724
1022	Ubiquitination	GLQVVAVKKLTRTQA CEEEEEEEECCCCCC	32.12	22505724
1034	Ubiquitination	TQASTVCTWSQERAC CCCCCCCCCCHHHHC	24.66	22505724
1060	Ubiquitination	HSVSCVIASDKENVT EEEEEEEEECCCCEE	7.41	22505724
1065	N-linked_Glycosylation	VIASDKENVTVAAEI EEEECCCCEEEEEEE	40.26	UniProtKB CARBOHYD
1096	N-linked_Glycosylation	ILGEISFNKSLYEGL EEEEEECCCHHHHCC	26.64	UniProtKB CARBOHYD
1098	Phosphorylation	GEISFNKSLYEGLNA EEEECCCHHHHCCCC	36.97	22210691
1100	Phosphorylation	ISFNKSLYEGLNAEN EECCCHHHHCCCCCC	18.29	22210691
1110	Phosphorylation	LNAENHRTKITVVFL CCCCCCCEEEEEEEE	21.17	22210691
1163	Phosphorylation	YQQLNLESIRKAQLK HHHCCHHHHHHHHHH	30.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITAE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITAE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITAE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EED_HUMAN	EED	physical	9765275

Drug and Disease Associations

• Kegg Disease
• H00006: Hairy-cell leukemia
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D09901: Etrolizumab (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.