IRS4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IRS4_MOUSE
• UniProt AC: Q9Z0Y7
• Protein Name: Insulin receptor substrate 4
• Gene Name: Irs4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1216
• Subcellular Localization: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2..
• Protein Sequence: MASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTALIGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYRNARKFRHSVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGALPDGEPAALAAAAAAEPPFYKDVWQVVVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDSVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSTRRHLGLLPLEPGGWLRRYGLEQFCRLRAIREREEMLFTRRFISPREPPPPFRRGRGHLPRARRSRRAASVPPSLFRRSAPSPGRIPQPEDVPNDRAREASGSSSGNTEEKDKEGEEGNRGDCIPMNNWGSGNGRGSGGGRGSSGQGSSSQGSGGRQGSGGGQGSGGQGAGGNQCSGNGQGTAGGHGSGGGGHGSGGGQRPGDGHGSGGGKNSGSGKNSDDGDRGKSVKKRSYFGKFTQSKQQQTLPPPPPPPPAAGATGGKGKSGGRFRLYFCADRGTKERKEAKEVRDMETSGGATRGPYRARAFDEDEDDPYVPMRPGVAAPLACSSDYMPMAPQNSSASTKRHSRSPFEDSRGYMMMFPRVSPPPPVPSAPKAPDTNKGDDSKDNDSDSDYMFMAPGAGAIPKNPPNAQGGSSSKSWSSYFSLPSPFQSSPLGQSDHSEYVPMLPGKFLGSGLHKEASFSQGTKNVSSKPSTEASFSKPEDKGSSAKPSDDVPPMNKAKEPNHLSFIAKGTQVKPKPLNPTQERREAAGSRDYINIDFIKRERLVLPSSAQGLPDMRGVVTDPAPTAFSGYLNVEFGVPFPNPTIRLSDLLRVLPGANSIPLAGTRWPFPGSAIGSIVEAGEYIEVIFNPAMTPAMSFADSAICYDAQTGQIYVVDPFSECCMDVSLSPGRCSEPPPVARLRREEAQERRRPQSRSQSLFASTRAAVSAFPTDSLDRDFPAASAVIAAPAEAPLLAVSRALAVVSALAAAPSIGDVFAGFRAAAGVDSASARGFQPVAGAQAVREFQDLAAGWNPGALNHRARGEDLAAGAAAPPPPPRQIWVLRPQERADSEDDDDDDDDIYVRMDFARRDYRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	IILYQCFSVSQRADA EEEEEECCHHHHHCH	28.60	-
158	Phosphorylation	LYQCFSVSQRADARY EEEECCHHHHHCHHH	16.86	-
252	Phosphorylation	LGHRKELSGVFRLCL CCCHHHHCCEEEEEC	33.72	29109428
439	Phosphorylation	LFRRSAPSPGRIPQP HHCCCCCCCCCCCCC	39.44	28382018
640	Acetylation	DRGTKERKEAKEVRD CCCHHHHHHHHHHHH	64.22	22902405
643	Acetylation	TKERKEAKEVRDMET HHHHHHHHHHHHCCC	58.81	22902405
707	Phosphorylation	STKRHSRSPFEDSRG CCCCCCCCCCCCCCC	36.63	29899451
819	Phosphorylation	SGLHKEASFSQGTKN CCCCCCCCCCCCCCC	26.90	28382018
894	Phosphorylation	EAAGSRDYINIDFIK HHHCCCCCEECEEEE	8.51	-
1059	Phosphorylation	RPQSRSQSLFASTRA CCCHHHHHHHHHHHH	27.05	20139300
1063	Phosphorylation	RSQSLFASTRAAVSA HHHHHHHHHHHHHHC	15.87	20139300
1064	Phosphorylation	SQSLFASTRAAVSAF HHHHHHHHHHHHHCC	22.39	20139300
1075	Phosphorylation	VSAFPTDSLDRDFPA HHCCCCCCCCCCCCC	34.35	26370283
1193	Phosphorylation	RPQERADSEDDDDDD CHHHCCCCCCCCCCC	41.77	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IRS4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IRS4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IRS4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASB4_MOUSE	Asb4	physical	21955513

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.