dbPTM

IRF5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRF5_MOUSE
UniProt AC	P56477
Protein Name	Interferon regulatory factor 5
Gene Name	Irf5
Organism	Mus musculus (Mouse).
Sequence Length	497
Subcellular Localization	Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm.
Protein Description	Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling (By similarity)..
Protein Sequence	MNHSAPGIPPPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFYIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFQLFYDGPRDMPPQPYKIYEVCSNGPAPTESQPTDDYVLGEEEEEEEEELQRMLPGLSITEPALPGPPNAPYSLPKEDTKWPPALQPPVGLGPPVPDPNLLAPPSGNPAGFRQLLPEVLEPGPLASSQPPTEPLLPDLLISPHMLPLTDLEIKFQYRGRAPRTLTISNPQGCRLFYSQLEATQEQVELFGPVTLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCALAHGSCPNPIQREVKTKLFSLEQFLNELILFQKGQTNTPPPFEIFFCFGEEWPDVKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDHMVEQFKELHHLWQSQQQLQPMVQAPPVAGLDASQGPWPMHPVGMQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNHSAPGIPPP ----CCCCCCCCCCC	31.02	27180971
74	Nitration	WAKETGKYTEGVDEA HHHHHCCCCCCCCCC	16.03	-
96	Malonylation	NLRCALNKSRDFQLF HHHHHHCCCCCCEEE	47.95	26320211
136	Phosphorylation	ESQPTDDYVLGEEEE CCCCCCCCCCCCHHH	10.61	24224561
157	Phosphorylation	QRMLPGLSITEPALP HHHCCCCCCCCCCCC	33.12	-
271	Glutathionylation	TISNPQGCRLFYSQL EECCCCCEEEEHHHH	2.62	24333276
300	Phosphorylation	LEQVRFPSPEDIPSD EEEECCCCHHHCCCH	37.90	-
334	Phosphorylation	QLQGQDLYAIRLCQC EECCCCEEEEEECCC	14.31	-
410	Ubiquitination	PDVKPREKKLITVQV CCCCCCCCCCEEEEH	54.91	18824541
411	Ubiquitination	DVKPREKKLITVQVV CCCCCCCCCEEEEHH	40.13	18824541
414	Phosphorylation	PREKKLITVQVVPVA CCCCCCEEEEHHHHH	18.47	26239621
430	Phosphorylation	RLLLEMFSGELSWSA HHHHHHHCCCCCCCC	30.01	25326420
434	Phosphorylation	EMFSGELSWSADSIR HHHCCCCCCCCEEEE	18.06	25326420
436	Phosphorylation	FSGELSWSADSIRLQ HCCCCCCCCEEEEEE	20.87	25326420
439	Phosphorylation	ELSWSADSIRLQISN CCCCCCEEEEEEECC	14.88	-
445	Phosphorylation	DSIRLQISNPDLKDH EEEEEEECCCCHHHH	29.37	25326420

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
157	S	Phosphorylation	Kinase	TBK1	Q9WUN2	Uniprot
434	S	Phosphorylation	Kinase	IKKB	O88351	Uniprot
445	S	Phosphorylation	Kinase	IKKB	O88351	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRF5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRF5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBC_MOUSE	Ubc	physical	18824541
TRAF6_MOUSE	Traf6	physical	18824541

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRF5_MOUSE

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"Functional regulation of MyD88-activated interferon regulatory factor5 by K63-linked polyubiquitination."; Balkhi M.Y., Fitzgerald K.A., Pitha P.M.; Mol. Cell. Biol. 28:7296-7308(2008). Cited for: UBIQUITINATION AT LYS-410 AND LYS-411 BY TRAF6, AND SUBCELLULARLOCATION.	18824541 [Abstract]