IQCH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IQCH_HUMAN
• UniProt AC: Q86VS3
• Protein Name: IQ domain-containing protein H
• Gene Name: IQCH
• Organism: Homo sapiens (Human).
• Sequence Length: 1027
• Protein Description: May play a regulatory role in spermatogenesis..
• Protein Sequence: MAQNTENHDPVGSILIQIHEDLYQLKEKLTKFSPEEKGETLDIQSLETAIKRTEVGLRIHIEKYLNVVNQNVLTTSVNDESLYTPQASKWLLPTVIDQKSFIFPQESEGTFWQPQRQHSSSLPVFPRAKIKVSKLIKGSNISSLTVLPSSHCTDPYFTPIPVLQADAHKGILSMIERGLIPPTARITFQNPPITPRAAPLHSFDEARKIPTVATFTIPREPPPSPAEVKFFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWDYDFLIYDGVIDNTAPDFLAFKEHFSLAWGGIFSLLEHVEKFLRNYAIPEVKIKGNNLVALLPEFELTNKLTRYDLLSVLEDPAHVQMLINLPGQRYKGQDGNSEAAMKIQATWKCYKARKFFLFYRQQKWASGVIAIAWLLYCHKTRLKKILKESRQRHLENFRIRAKHLAANWNRIRTSRRTIIHIPSLGYSQPVREHIADFNTQQNMQLGRLCDILDANVNVIYICSHHMNDELVLYYKKILSLHAAVKSGNLEDRSDLQDRFKIITPEAVNIFPKHHMCLATHLMYSPKAIKRIKNLIRGTEAYIVSGLLHRDDLAVADMLDIPILGSEPELAHLYSTKSGGKRVFDSANVAVPPGIYDIYSQQQMIEQLSQLITDHLQIQRWLFKMDSEFRGNGTAFCDIPSYLKCYKWVLKESSRYGLEDWRKKWAQEPALVKISEELAGILAQHAQPVNEKRFPTWRKFLQTFLSQGGVIEAFPPADNVTNLTVDMLIEPNGKISVLSTGDQLHAESPFISSGTTVPQTSVDPQVLTYLCLQIGKACRMRDVVGYFSIDLVTFIDPSTLEQQVWATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIHQEISAPNMQGETNFKTTIADIETILRVTKENKMRFEEEQQSKDDKNLSKPKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	KEKLTKFSPEEKGET HHHHHCCCHHHCCCC	32.72	26074081
48	Phosphorylation	LDIQSLETAIKRTEV CCHHHHHHHHHHCCH	38.69	-
53	Phosphorylation	LETAIKRTEVGLRIH HHHHHHHCCHHHHEE	29.98	24702127
74	Phosphorylation	VVNQNVLTTSVNDES CCCCCEEECCCCCCC	16.85	25002506
75	Phosphorylation	VNQNVLTTSVNDESL CCCCEEECCCCCCCC	26.90	25002506
76	Phosphorylation	NQNVLTTSVNDESLY CCCEEECCCCCCCCC	17.43	25002506
81	Phosphorylation	TTSVNDESLYTPQAS ECCCCCCCCCCCCHH	29.55	25002506
83	Phosphorylation	SVNDESLYTPQASKW CCCCCCCCCCCHHHC	26.17	25002506
84	Phosphorylation	VNDESLYTPQASKWL CCCCCCCCCCHHHCC	17.76	25002506
88	Phosphorylation	SLYTPQASKWLLPTV CCCCCCHHHCCCCEE	21.08	25002506
158 (in isoform 5)	Phosphorylation	-	17.92	23684312
216	Phosphorylation	IPTVATFTIPREPPP CCEEEEEEECCCCCC	26.22	24719451
224	Phosphorylation	IPREPPPSPAEVKFF ECCCCCCCHHHCCCC	42.38	29743597
229	Acetylation	PPSPAEVKFFPKKQR CCCHHHCCCCCHHHC	32.56	30589521
233	Acetylation	AEVKFFPKKQRSKGK HHCCCCCHHHCCCCC	57.28	30589525
234	Acetylation	EVKFFPKKQRSKGKS HCCCCCHHHCCCCCC	51.70	30589529
422	Phosphorylation	LKKILKESRQRHLEN HHHHHHHHHHHHHHH	31.93	-
450	Phosphorylation	RIRTSRRTIIHIPSL HHHCCCCEEEECCCC	24.15	-
460	Phosphorylation	HIPSLGYSQPVREHI ECCCCCCCCCHHHHH	26.64	-
556	Phosphorylation	CLATHLMYSPKAIKR HHHHHHHCCHHHHHH	28.34	27251275
557	Phosphorylation	LATHLMYSPKAIKRI HHHHHHCCHHHHHHH	13.12	27251275
883	O-linked_Glycosylation	VPKERKKTKCMSALS CCCHHHCCCCHHHHC	32.29	31492838
887	Phosphorylation	RKKTKCMSALSMPML HHCCCCHHHHCCHHH	35.21	-
890	Phosphorylation	TKCMSALSMPMLATS CCCHHHHCCHHHHHC	22.13	-
899	Phosphorylation	PMLATSRYAVMTTQL HHHHHCCHHHHHHHC	11.87	-
1016	Phosphorylation	RFEEEQQSKDDKNLS CHHHHHHCCCCCCCC	37.43	30622161
1023	Phosphorylation	SKDDKNLSKPKK--- CCCCCCCCCCCC---	57.20	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IQCH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IQCH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IQCH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CBX6_HUMAN	CBX6	physical	26186194

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.