INX3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INX3_DROME
• UniProt AC: Q9VAS7
• Protein Name: Innexin inx3
• Gene Name: Inx3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 395
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction. Cytoplasm. Lateral cell membrane. Apicolateral cell membrane. In ovary, localizes to the lateral membrane of follicle cells covering the oocyte and to the apicolateral membran
• Protein Description: Structural components of the gap junctions. Essential for proper epithelial development of the epidermis..
• Protein Sequence: MAVFGMVSAVSGFIKIRYLLDKAVIDNMVFRCHYRITTAILFTCCIIVTANNLIGDPISCINDGAIPMHVINTFCWITYTYTIPGQQHRQIGTDVAGPGLGNEYGQEKRYHSYYQWVPFVLFFQGLMFYVPHWVWKNMEDGKIRMITDGLRGMVSVPDDYRRDRQDRILKYFVNSLNTHNGYSFAYFFCELLNFINVIVNIFMVDKFLGGAFMSYGTDVLKFSNMDQDKRFDPMIEIFPRLTKCTFHKFGPSGSVQKHDTLCVLALNILNEKIYIFLWFWFIILATISGVAVLYSLVVIMMPTTRETIIKRSYRSAQRKEIAGLVRRLEIGDFLILHFLSQNLSTRSYSDMLQQLCGLLGASRTPSAPSTLEMNRISHPIYPPVETFGGGKETET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
364	Phosphorylation	GLLGASRTPSAPSTL HHHCCCCCCCCCCCH	21.07	22817900
366	Phosphorylation	LGASRTPSAPSTLEM HCCCCCCCCCCCHHH	52.80	22817900
377	Phosphorylation	TLEMNRISHPIYPPV CHHHCCCCCCCCCCH	21.70	22817900
381	Phosphorylation	NRISHPIYPPVETFG CCCCCCCCCCHHHCC	13.11	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INX3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INX3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INX3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CADE_DROME	shg	physical	23894431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366; SER-377 ANDTYR-381, AND MASS SPECTROMETRY.
PubMed: 18327897