INSM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INSM2_HUMAN
• UniProt AC: Q96T92
• Protein Name: Insulinoma-associated protein 2
• Gene Name: INSM2
• Organism: Homo sapiens (Human).
• Sequence Length: 566
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons..
• Protein Sequence: MPRGFLVKRTKRTGGLYRVRLAERVFPLLGPQGAPPFLEEAPSASLPGAERATPPTREEPGKGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGREGPGPSPSPSPSPAKPAGAELRRAFLERCLSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPGEQFLLPLRAPFPEPALQPDPAPLSAALQSLKRAAGGERRGKAPTDCASGPAAAGIKKPKAMRKLSFADEVTTSPVLGLKIKEEEPGAPSRGLGGSRTPLGEFICQLCKEQYADPFALAQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPAAANAATVSSADGKPPSSSSSSSRDSGAIASFLAEGKENSRIERTADQHPQARDSSGADQHPDSAPRQGLQVLTHPEPPLPQGPYTEGVLGRRVPVPGSTSGGRGSEIFVCPYCHKKFRRQAYLRKHLSTHEAGSARALAPGFGSERGAPLAFACPLCGAHFPTADIREKHRLWHAVREELLLPALAGAPPETSGPSGPSDGSAQQIFSCKHCPSTFFSSPGLTRHINKCHPSESRQVLLLQMPLRPGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	PCRAAGVSPGTGGRE CCHHCCCCCCCCCCC	19.39	27732954
86	Phosphorylation	AAGVSPGTGGREGAE HCCCCCCCCCCCCCC	39.59	27732954
105	Phosphorylation	GREGPGPSPSPSPSP CCCCCCCCCCCCCCC	43.88	27732954
107	Phosphorylation	EGPGPSPSPSPSPAK CCCCCCCCCCCCCCC	42.20	22210691
109	Phosphorylation	PGPSPSPSPSPAKPA CCCCCCCCCCCCCCC	42.20	25404012
111	Phosphorylation	PSPSPSPSPAKPAGA CCCCCCCCCCCCCCH	41.65	27732954
149	Phosphorylation	AAAVAAFSCSVAPAA HHHHHHHCCCCCCCC	10.76	23403867
226	Phosphorylation	PKAMRKLSFADEVTT CHHHHHCCCCCCCCC	22.79	27732954
232	Phosphorylation	LSFADEVTTSPVLGL CCCCCCCCCCCCCCC	21.36	27732954
233	Phosphorylation	SFADEVTTSPVLGLK CCCCCCCCCCCCCCE	35.89	27732954
234	Phosphorylation	FADEVTTSPVLGLKI CCCCCCCCCCCCCEE	12.02	27732954
258	Phosphorylation	RGLGGSRTPLGEFIC CCCCCCCCHHHHHHH	25.27	27732954
334	Phosphorylation	SADGKPPSSSSSSSR CCCCCCCCCCCCCCC	51.91	27732954
335	Phosphorylation	ADGKPPSSSSSSSRD CCCCCCCCCCCCCCC	39.76	27732954
336	Phosphorylation	DGKPPSSSSSSSRDS CCCCCCCCCCCCCCC	38.28	27732954
337	Phosphorylation	GKPPSSSSSSSRDSG CCCCCCCCCCCCCCC	35.87	25954137
338	Phosphorylation	KPPSSSSSSSRDSGA CCCCCCCCCCCCCCH	33.99	25954137
339	Phosphorylation	PPSSSSSSSRDSGAI CCCCCCCCCCCCCHH	31.19	25954137
340	Phosphorylation	PSSSSSSSRDSGAIA CCCCCCCCCCCCHHH	41.89	25954137
343	Phosphorylation	SSSSSRDSGAIASFL CCCCCCCCCHHHHHH	29.07	25954137
348	Phosphorylation	RDSGAIASFLAEGKE CCCCHHHHHHHCCCC	18.06	-
416	Phosphorylation	RRVPVPGSTSGGRGS CCCCCCCCCCCCCCC	17.21	27732954
417	Phosphorylation	RVPVPGSTSGGRGSE CCCCCCCCCCCCCCC	36.99	27732954
418	Phosphorylation	VPVPGSTSGGRGSEI CCCCCCCCCCCCCCE	40.73	27732954
446	Phosphorylation	AYLRKHLSTHEAGSA HHHHHHHHHCCCCCH	27.69	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INSM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INSM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INSM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZSCA1_HUMAN	ZSCAN1	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.