INSM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INSM1_HUMAN
• UniProt AC: Q01101
• Protein Name: Insulinoma-associated protein 1
• Gene Name: INSM1
• Organism: Homo sapiens (Human).
• Sequence Length: 510
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation..
• Protein Sequence: MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPPAERAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAARGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RGFLVKRSKKSTPVS CCEEEECCCCCCCCE	38.42	28258704
13	Phosphorylation	LVKRSKKSTPVSYRV EEECCCCCCCCEEEE	41.50	26657352
14	Phosphorylation	VKRSKKSTPVSYRVR EECCCCCCCCEEEEC	36.27	26657352
17	Phosphorylation	SKKSTPVSYRVRGGE CCCCCCCEEEECCCC	14.39	26657352
18	Phosphorylation	KKSTPVSYRVRGGED CCCCCCEEEECCCCC	17.23	28258704
100	Phosphorylation	AAHPAPLYSPTRPVS CCCCCCCCCCCCCCC	16.14	27732954
101	Phosphorylation	AHPAPLYSPTRPVSR CCCCCCCCCCCCCCC	27.72	27732954
103	Phosphorylation	PAPLYSPTRPVSREH CCCCCCCCCCCCCHH	41.48	27732954
107	Phosphorylation	YSPTRPVSREHEKHK CCCCCCCCCHHHHHH	34.33	27732954
347	Phosphorylation	REAPGGGSDRDTPSP HHCCCCCCCCCCCCC	32.52	27251275
351	Phosphorylation	GGGSDRDTPSPGGVS CCCCCCCCCCCCCCC	26.93	27251275
353	Phosphorylation	GSDRDTPSPGGVSES CCCCCCCCCCCCCCC	37.97	27251275
358	Phosphorylation	TPSPGGVSESGSEDG CCCCCCCCCCCCCCC	29.35	-
360	Phosphorylation	SPGGVSESGSEDGLY CCCCCCCCCCCCCCH	39.86	27251275
362	Phosphorylation	GGVSESGSEDGLYEC CCCCCCCCCCCCHHH	41.62	27251275
480	Phosphorylation	YCPATFYSSPGLTRH CCCCCCCCCCCHHHH	26.35	28348404
481	Phosphorylation	CPATFYSSPGLTRHI CCCCCCCCCCHHHHH	16.17	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INSM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INSM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INSM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCND1_HUMAN	CCND1	physical	16569215
HDAC1_HUMAN	HDAC1	physical	16569215
HDAC3_HUMAN	HDAC3	physical	16569215

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.