IMUP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMUP_HUMAN
• UniProt AC: Q9GZP8
• Protein Name: Immortalization up-regulated protein
• Gene Name: IMUP
• Organism: Homo sapiens (Human).
• Sequence Length: 106
• Subcellular Localization: Nucleus .
• Protein Sequence: MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPGPKQGHHSSSDSSSSSSDSDTDVKSHAAGSKQHESIPGKAKKPKVKKKEKGKKEKGKKKEAPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEFDLGAA -------CCCCCCCC	11.91	20068231
12	Phosphorylation	LGAALEPTSQKPGVG CCCCCCCCCCCCCCC	34.12	22167270
13	Phosphorylation	GAALEPTSQKPGVGA CCCCCCCCCCCCCCC	47.09	23663014
15	Acetylation	ALEPTSQKPGVGAGH CCCCCCCCCCCCCCC	43.43	23954790
29	Phosphorylation	HGGDPKLSPHKVQGR CCCCCCCCCCCCCCC	30.96	22167270
37	Phosphorylation	PHKVQGRSEAGAGPG CCCCCCCCCCCCCCC	38.33	25849741
37 (in isoform 2)	Phosphorylation	-	38.33	-
51	Phosphorylation	GPKQGHHSSSDSSSS CCCCCCCCCCCCCCC	26.34	28176443
52	Phosphorylation	PKQGHHSSSDSSSSS CCCCCCCCCCCCCCC	33.53	28176443
53	Phosphorylation	KQGHHSSSDSSSSSS CCCCCCCCCCCCCCC	44.52	28176443
55	Phosphorylation	GHHSSSDSSSSSSDS CCCCCCCCCCCCCCC	33.78	28176443
56	Phosphorylation	HHSSSDSSSSSSDSD CCCCCCCCCCCCCCC	38.95	28176443
57	Phosphorylation	HSSSDSSSSSSDSDT CCCCCCCCCCCCCCC	37.89	28176443
58	Phosphorylation	SSSDSSSSSSDSDTD CCCCCCCCCCCCCCH	35.49	28176443
59	Phosphorylation	SSDSSSSSSDSDTDV CCCCCCCCCCCCCHH	39.86	28176443
60	Phosphorylation	SDSSSSSSDSDTDVK CCCCCCCCCCCCHHH	42.98	28176443
62	Phosphorylation	SSSSSSDSDTDVKSH CCCCCCCCCCHHHHH	44.34	25849741
64	Phosphorylation	SSSSDSDTDVKSHAA CCCCCCCCHHHHHHH	46.79	28176443
73	Phosphorylation	VKSHAAGSKQHESIP HHHHHHHCCCCCCCC	25.15	-
74	Ubiquitination	KSHAAGSKQHESIPG HHHHHHCCCCCCCCC	55.55	29967540
78	Phosphorylation	AGSKQHESIPGKAKK HHCCCCCCCCCCCCC	31.77	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMUP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMUP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMUP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
XIAP_HUMAN	XIAP	physical	22886722

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29, AND MASSSPECTROMETRY.
PubMed: 17081983