IL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL4_HUMAN
• UniProt AC: P05112
• Protein Name: Interleukin-4
• Gene Name: IL4
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Subcellular Localization: Secreted.
• Protein Description: Participates in at least several B-cell activation processes as well as of other cell types. [PubMed: 3016727 It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity]
• Protein Sequence: MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	DIFAASKNTTEKETF HHHHHCCCCCCHHHH	50.14	1993171
68	Phosphorylation	KNTTEKETFCRAATV CCCCCHHHHHHHHHH	38.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL4RA_HUMAN	IL4R	physical	11786020

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601367: Ischemic stroke (ISCHSTR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Disulfide assignments in recombinant mouse and human interleukin 4.";
Carr C., Aykent S., Kimack N.M., Levine A.D.;
Biochemistry 30:1515-1523(1991).
Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-62, AND DISULFIDEBONDS.
PubMed: 1993171