dbPTM

IL4RA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IL4RA_MOUSE
UniProt AC	P16382
Protein Name	Interleukin-4 receptor subunit alpha
Gene Name	Il4r
Organism	Mus musculus (Mouse).
Sequence Length	810
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Isoform 2: Secreted.
Protein Description	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2..
Protein Sequence	MGRLCTKFLTSVGCLILLLVTGSGSIKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRLPLGVTISCLCIPLFCLFCYFSITKIKKIWWDQIPTPARSPLVAIIIQDAQVPLWDKQTRSQESTKYPHWKTCLDKLLPCLLKHRVKKKTDFPKAAPTKSLQSPGKAGWCPMEVSRTVLWPENVSVSVVRCMELFEAPVQNVEEEEDEIVKEDLSMSPENSGGCGFQESQADIMARLTENLFSDLLEAENGGLGQSALAESCSPLPSGSGQASVSWACLPMGPSEEATCQVTEQPSHPGPLSGSPAQSAPTLACTQVPLVLADNPAYRSFSDCCSPAPNPGELAPEQQQADHLEEEEPPSPADPHSSGPPMQPVESWEQILHMSVLQHGAAAGSTPAPAGGYQEFVQAVKQGAAQDPGVPGVRPSGDPGYKAFSSLLSSNGIRGDTAAAGTDDGHGGYKPFQNPVPNQSPSSVPLFTFGLDTELSPSPLNSDPPKSPPECLGLELGLKGGDWVKAPPPADQVPKPFGDDLGFGIVYSSLTCHLCGHLKQHHSQEEGGQSPIVASPGCGCCYDDRSPSLGSLSGALESCPEGIPPEANLMSAPKTPSNLSGEGKGPGHSPVPSQTTEVPVGALGIAVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	N-linked_Glycosylation	MFFEFSENLTCIPRN HEEECCCCEEEECCC	39.18	-
129	N-linked_Glycosylation	VKPLAPDNLTLHTNV CCCCCCCCEEEEECC	33.59	-
135	N-linked_Glycosylation	DNLTLHTNVSDEWLL CCEEEEECCCCCEEE	22.13	-
163	N-linked_Glycosylation	KDLISMVNISREDNP HHHHHHHCCCCCCCC	20.20	-
165	Phosphorylation	LISMVNISREDNPAE HHHHHCCCCCCCCCE	25.14	19144319
186	Phosphorylation	TYKEPRLSFPINILM ECCCCCCCCEEEEEE	30.20	25777480
194	Phosphorylation	FPINILMSGVYYTAR CEEEEEECCCEEEEE	22.97	25777480
197	Phosphorylation	NILMSGVYYTARVRV EEEECCCEEEEEEEE	9.91	25777480
198	Phosphorylation	ILMSGVYYTARVRVR EEECCCEEEEEEEEE	7.48	25777480
199	Phosphorylation	LMSGVYYTARVRVRS EECCCEEEEEEEEEE	7.12	25777480
300	Phosphorylation	RSQESTKYPHWKTCL CCCCCCCCCCHHHHH	10.62	-
333	Phosphorylation	PKAAPTKSLQSPGKA CCCCCCCCCCCCCCC	33.83	28285833
500	Phosphorylation	VLADNPAYRSFSDCC EECCCHHHCCHHHHC	14.19	14557412
575	Phosphorylation	TPAPAGGYQEFVQAV CCCCCCCHHHHHHHH	12.17	8390454
603	Phosphorylation	RPSGDPGYKAFSSLL CCCCCCCHHHHHHHH	12.44	8390454
607	Phosphorylation	DPGYKAFSSLLSSNG CCCHHHHHHHHHHCC	25.57	24719451
631	Phosphorylation	TDDGHGGYKPFQNPV CCCCCCCCCCCCCCC	21.78	8390454
748	Phosphorylation	GCCYDDRSPSLGSLS CCCCCCCCCCHHHHC	26.32	28285833
773	Phosphorylation	PPEANLMSAPKTPSN CCCCCCCCCCCCCCC	44.58	28285833
791	Phosphorylation	EGKGPGHSPVPSQTT CCCCCCCCCCCCCCC	33.24	26643407
795	Phosphorylation	PGHSPVPSQTTEVPV CCCCCCCCCCCCCCC	40.15	26643407
797	Phosphorylation	HSPVPSQTTEVPVGA CCCCCCCCCCCCCCC	29.30	26643407
798	Phosphorylation	SPVPSQTTEVPVGAL CCCCCCCCCCCCCCC	27.61	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IL4RA_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IL4RA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IL4RA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT6_MOUSE	Stat6	physical	15661890
CHIP_MOUSE	Stub1	physical	24251647
HS71B_MOUSE	Hspa1b	physical	24251647

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IL4RA_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.	19144319 [Abstract]