IL25_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL25_HUMAN
• UniProt AC: Q9H293
• Protein Name: Interleukin-25
• Gene Name: IL25
• Organism: Homo sapiens (Human).
• Sequence Length: 177
• Subcellular Localization: Secreted.
• Protein Description: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses..
• Protein Sequence: MRERPRLGEDSSLISLFLQVVAFLAMVMGTHTYSHWPSCCPSKGQDTSEELLRWSTVPVPPLEPARPNRHPESCRASEDGPLNSRAISPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPRGNSELLYHNQTVFYRRPCHGEKGTHKGYCLERRLYRVSLACVCVRPRVMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	PSKGQDTSEELLRWS CCCCCCCCHHHHCCC	37.05	-
92	Phosphorylation	RAISPWRYELDRDLN CCCCCHHHHHHCHHH	19.58	-
136	N-linked_Glycosylation	NSELLYHNQTVFYRR CCEEEEECCEEEEEC	26.17	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL25_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL25_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL25_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
I17RB_HUMAN	IL17RB	physical	11058597

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.