IKBD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKBD_HUMAN
• UniProt AC: Q8NI38
• Protein Name: NF-kappa-B inhibitor delta
• Gene Name: NFKBID
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Nucleus .
• Protein Description: Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). May also regulate TCR-induced negative selection of thymocytes..
• Protein Sequence: MEAGPWRVSAPPSGPPQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRVAPPGLSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
200	Phosphorylation	LQMGANHTSQEIKSN HHCCCCCCCHHHHCC	31.73	-
201	Phosphorylation	QMGANHTSQEIKSNK HCCCCCCCHHHHCCC	20.47	-
312	Phosphorylation	RVAPPGLSS------ CCCCCCCCC------	39.66	30108239
313	Phosphorylation	VAPPGLSS------- CCCCCCCC-------	49.65	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKBD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKBD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKBD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CA094_HUMAN	C1orf94	physical	25416956
TRIM9_HUMAN	TRIM9	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
NFKB1_HUMAN	NFKB1	physical	28514442
REL_HUMAN	REL	physical	28514442
NFKB2_HUMAN	NFKB2	physical	28514442
XPF_HUMAN	ERCC4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.