IF5A1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5A1_SCHPO
• UniProt AC: P56289
• Protein Name: Eukaryotic translation initiation factor 5A-1
• Gene Name: tif51a
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 157
• Subcellular Localization: Cytoplasm.
• Protein Description: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity)..
• Protein Sequence: MAEEEHVDFEGGEAGASLTFPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHIVALDIFNGRKYEDMSPSTHNMDVPVVKRDEYQLVNIDDGYLNLMTTDGTTKDDVRLPEGELGNEIEEGFDEGRDLIITVVSAMGEETALACRDAPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	PCKIVDMSTSKTGKH ECEEEECCCCCCCCC	25.68	27738172
52	Hypusine	MSTSKTGKHGHAKVH CCCCCCCCCCCEEEE	52.20	-
52	Other	MSTSKTGKHGHAKVH CCCCCCCCCCCEEEE	52.20	-
75	Phosphorylation	GRKYEDMSPSTHNMD CCCCCCCCCCCCCCC	28.20	28889911
77	Phosphorylation	KYEDMSPSTHNMDVP CCCCCCCCCCCCCCC	34.68	28889911
78	Phosphorylation	YEDMSPSTHNMDVPV CCCCCCCCCCCCCCC	22.21	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5A1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5A1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5A1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHYS_SCHPO	SPBC1271.04c	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-77 AND THR-78,AND MASS SPECTROMETRY.
PubMed: 18257517