HXD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXD3_HUMAN
• UniProt AC: P31249
• Protein Name: Homeobox protein Hox-D3
• Gene Name: HOXD3
• Organism: Homo sapiens (Human).
• Sequence Length: 432
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MLFEQGQQALELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYSTPHQPYPPPAAASSLDTDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLTHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	GGYGYSKTTDTYGYS CCCCCCCCCCCCCCC	24.78	-
38	Phosphorylation	GYGYSKTTDTYGYST CCCCCCCCCCCCCCC	30.04	-
165	Ubiquitination	KQIFPWMKESRQNSK HHHHHHHHHHHHCHH	48.98	29967540
179	Phosphorylation	KQKNSCATAGESCED HCCCCCCCCCCCCCC	39.25	30177828
183	Phosphorylation	SCATAGESCEDKSPP CCCCCCCCCCCCCCC	23.14	27732954
188	Phosphorylation	GESCEDKSPPGPASK CCCCCCCCCCCCCHH	48.96	27732954
194	Phosphorylation	KSPPGPASKRVRTAY CCCCCCCHHHHHHHH	24.91	27732954
261	Phosphorylation	KAKGILHSPASQSPE CCCCCCCCCCHHCCC	20.79	25850435
264	Phosphorylation	GILHSPASQSPERSP CCCCCCCHHCCCCCC	34.28	27732954
266	Phosphorylation	LHSPASQSPERSPPL CCCCCHHCCCCCCCC	26.66	25850435
270	Phosphorylation	ASQSPERSPPLGGAA CHHCCCCCCCCCCCC	29.25	25921289
283	Phosphorylation	AAGHVAYSGQLPPVP CCCEEEECCCCCCCC	15.43	25921289
298	Phosphorylation	GLAYDAPSPPAFAKS CCCCCCCCCCHHHHC	45.28	25921289

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALX4_HUMAN	ALX4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.