HVCN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HVCN1_HUMAN
• UniProt AC: Q96D96
• Protein Name: Voltage-gated hydrogen channel 1
• Gene Name: HVCN1
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
• Protein Description: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis..
• Protein Sequence: MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MATWDEKAVTRRAK -CCCCCHHHHHHHHC	45.76	-
15 (in isoform 4)	Phosphorylation	-	8.23	27155012
23	Ubiquitination	APAERMSKFLRHFTV CCHHHHHHHHHHCEE	38.79	21890473
29	Phosphorylation	SKFLRHFTVVGDDYH HHHHHHCEEECCCCH	14.25	28857561
35	Phosphorylation	FTVVGDDYHAWNINY CEEECCCCHHHCCCC	9.74	29978859
42	Phosphorylation	YHAWNINYKKWENEE CHHHCCCCCCCCCHH	15.33	22817900
43	Ubiquitination	HAWNINYKKWENEEE HHHCCCCCCCCCHHH	47.09	21890473
43	Ubiquitination	HAWNINYKKWENEEE HHHCCCCCCCCCHHH	47.09	21890473
43 (in isoform 1)	Ubiquitination	-	47.09	21890473
43 (in isoform 2)	Ubiquitination	-	47.09	21890473
43 (in isoform 3)	Ubiquitination	-	47.09	21890473
60	Phosphorylation	EEEQPPPTPVSGEEG HHCCCCCCCCCCCCC	41.94	22617229
63	Phosphorylation	QPPPTPVSGEEGRAA CCCCCCCCCCCCCCC	41.51	30576142
90	Ubiquitination	RAPLDFRGMLRKLFS CCCCCHHHHHHHHHC	21.33	21890473
97	Phosphorylation	GMLRKLFSSHRFQVI HHHHHHHCCCCHHHH	35.35	14702039
232	Ubiquitination	ERQLLRLKQMNVQLA HHHHHHHHHHCHHHH	40.86	29967540
252	Acetylation	LEFSCSEKEQEIERL HHHCCCHHHHHHHHH	48.69	23749302
252	Ubiquitination	LEFSCSEKEQEIERL HHHCCCHHHHHHHHH	48.69	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
9	T	Phosphorylation	Kinase	PKCD	Q05655	PSP
29	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS
77	S	Phosphorylation	Kinase	PKCD	Q05655	PSP
97	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HVCN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HVCN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUCL1_HUMAN	MUCL1	physical	26186194
PIGR_HUMAN	PIGR	physical	26186194
OXLD1_HUMAN	OXLD1	physical	26186194
CYTN_HUMAN	CST1	physical	26186194
CYTT_HUMAN	CST2	physical	26186194
DOK2_HUMAN	DOK2	physical	26186194
OXLD1_HUMAN	OXLD1	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
DOK2_HUMAN	DOK2	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
MUCL1_HUMAN	MUCL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.