HTRA2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HTRA2_DROME
• UniProt AC: Q9VFJ3
• Protein Name: Serine protease HTRA2, mitochondrial {ECO:0000303|PubMed:18259196}
• Gene Name: HtrA2 {ECO:0000312|FlyBase:FBgn0038233}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 422
• Subcellular Localization: Mitochondrion intermembrane space ; Single-pass membrane protein . Mitochondrion membrane ; Single-pass membrane protein . Predominantly present in the intermembrane space (PubMed:17397804, PubMed:18259196). Released into the cytosol following apopto
• Protein Description: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th..
• Protein Sequence: MALRGSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAIIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPEDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of HTRA2_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HTRA2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HTRA2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HTRA2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DIAP1_DROME	th	genetic	18259196
DIAP2_DROME	Iap2	physical	18259196
DIAP1_DROME	th	physical	18259196

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.