HPLN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPLN1_HUMAN
• UniProt AC: P10915
• Protein Name: Hyaluronan and proteoglycan link protein 1
• Gene Name: HAPLN1
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix..
• Protein Sequence: MKSLLLLVLISICWADHLSDNYTLDHDRAIHIQAENGPHLLVEAEQAKVFSHRGGNVTLPCKFYRDPTAFGSGIHKIRIKWTKLTSDYLKEVDVFVSMGYHKKTYGGYQGRVFLKGGSDSDASLVITDLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVVFPYFPRLGRYNLNFHEAQQACLDQDAVIASFDQLYDAWRGGLDWCNAGWLSDGSVQYPITKPREPCGGQNTVPGVRNYGFWDKDKSRYDVFCFTSNFNGRFYYLIHPTKLTYDEAVQACLNDGAQIAKVGQIFAAWKILGYDRCDAGWLADGSVRYPISRPRRRCSPTEAAVRFVGFPDKKHKLYGVYCFRAYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	N-linked_Glycosylation	WADHLSDNYTLDHDR HHHHCCCCCCCCCCC	28.45	UniProtKB CARBOHYD
56	N-linked_Glycosylation	VFSHRGGNVTLPCKF EEEECCCCEEEECEE	26.82	UniProtKB CARBOHYD
64	Phosphorylation	VTLPCKFYRDPTAFG EEEECEEEECCCCCC	10.29	-
72	Phosphorylation	RDPTAFGSGIHKIRI ECCCCCCCCEEEEEE	28.28	24114839
100	Phosphorylation	DVFVSMGYHKKTYGG CEEEECCCCCCCCCC	11.21	-
105	Phosphorylation	MGYHKKTYGGYQGRV CCCCCCCCCCEECEE	19.89	22817900
108	Phosphorylation	HKKTYGGYQGRVFLK CCCCCCCEECEEEEC	11.93	17494752
118	Phosphorylation	RVFLKGGSDSDASLV EEEECCCCCCCCEEE	42.48	29396449
120	Phosphorylation	FLKGGSDSDASLVIT EECCCCCCCCEEEEE	36.45	29396449
123	Phosphorylation	GGSDSDASLVITDLT CCCCCCCEEEEECCC	28.32	29396449
127	Phosphorylation	SDASLVITDLTLEDY CCCEEEEECCCHHHH	19.92	29396449
130	Phosphorylation	SLVITDLTLEDYGRY EEEEECCCHHHHCCE	30.80	29396449
134	Phosphorylation	TDLTLEDYGRYKCEV ECCCHHHHCCEEEEE	8.30	-
328	Phosphorylation	PRRRCSPTEAAVRFV CCCCCCHHHHHHHHC	23.20	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPLN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPLN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPLN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.