HMGB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMGB4_HUMAN
• UniProt AC: Q8WW32
• Protein Name: High mobility group protein B4
• Gene Name: HMGB4
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Nucleus . Chromosome.
• Protein Sequence: MGKEIQLKPKANVSSYVHFLLNYRNKFKEQQPNTYVGFKEFSRKCSEKWRSISKHEKAKYEALAKLDKARYQEEMMNYVGKRKKRRKRDPQEPRRPPSSFLLFCQDHYAQLKRENPNWSVVQVAKATGKMWSTATDLEKHPYEQRVALLRAKYFEELELYRKQCNARKKYRMSARNRCRGKRVRQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LKPKANVSSYVHFLL CCCCCCHHHHHHHHH	18.76	26074081
15	Phosphorylation	KPKANVSSYVHFLLN CCCCCHHHHHHHHHH	27.22	26074081
16	Phosphorylation	PKANVSSYVHFLLNY CCCCHHHHHHHHHHC	7.16	26074081
23	Phosphorylation	YVHFLLNYRNKFKEQ HHHHHHHCHHHHCCC	18.61	26074081
34	Phosphorylation	FKEQQPNTYVGFKEF HCCCCCCCEECHHHH	26.68	26074081
35	Phosphorylation	KEQQPNTYVGFKEFS CCCCCCCEECHHHHH	12.76	26074081
71	Phosphorylation	AKLDKARYQEEMMNY HHHHHHHHHHHHHHH	25.74	29978859
78	Phosphorylation	YQEEMMNYVGKRKKR HHHHHHHHHHHHHHH	7.84	29978859
98	Phosphorylation	QEPRRPPSSFLLFCQ CCCCCCCHHHHHHHH	36.08	30622161
99	Phosphorylation	EPRRPPSSFLLFCQD CCCCCCHHHHHHHHH	26.20	30622161
119	Phosphorylation	KRENPNWSVVQVAKA HHHCCCCCHHHHHHH	21.03	29978859
162	Ubiquitination	EELELYRKQCNARKK HHHHHHHHHHHHHHH	45.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMGB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMGB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMGB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KR124_HUMAN	KRTAP12-4	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.